Evidence map›Paper›PMID 31306743›Full record

ArticleToxicology letters2019

Early chronic low-level lead exposure reduced C-C chemokine receptor 7 in hippocampal microglia.

Mayra Gisel Flores-Montoya, Colin A Bill, Charlotte M Vines, Christina Sobin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mayra Gisel Flores-MontoyaDept of Psychology, The University of Texas at El Paso, El Paso, TX, USA; Dept of Psychology, Carleton College, Northfield, MN, USA. Electronic address: mflores@carleton.edu.
Colin A BillDept of Biological Sciences, The University of Texas at El Paso, El Paso, TX, USA.
Charlotte M VinesDept of Biological Sciences, The University of Texas at El Paso, El Paso, TX, USA.
Christina SobinDept of Public Health Sciences, The University of Texas at El Paso, El Paso, TX, USA; Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA.
The University of Texas at El Paso · US

Funding

TOXICOLOGY PROJECTG12RR008124 · NCRR · UNIVERSITY OF TEXAS EL PASO · PI WALSH, ELIZABETH J · 1992 to 2011
$20.8M
TCCG12MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI KIRKEN, ROBERT A. · 2012 to 2018
$19.4M
CCR7 Chemotaxis Regulates Memory T Cell LocalizationSC1GM111172 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI VINES, CHARLOTTE M · 2015 to 2023
$3.0M
Lead, Genes, and Cognition in Underserved ChildrenR21HD060120 · NICHD · UNIVERSITY OF TEXAS EL PASO · PI SOBIN, CHRISTINA · 2009 to 2010
$488k
NCRR NIH HHS G12 RR008124NICHD NIH HHS R21 HD060120NIGMS NIH HHS SC1 GM111172NIMHD NIH HHS G12 MD007592
6 · The paper itself

Abstract

Chronic low-level lead exposure alters cognitive function in young children however the mechanisms mediating these deficits in the brain are not known. Previous studies in our laboratory showed that early lead exposure reduced the number of microglial cells in hippocampus/dentate gyrus of C57BL/6 J mice. In the current study, C-C chemokine receptor 7 (CCR7) and major histocompatibility complex II (MHC II) were examined to investigate whether these neuroimmune factors which are known to trigger cell migration and antigen presentation, were altered by early chronic lead exposure. Thirty-six C57BL/6 J male mice were exposed to 0 ppm (controls, n = 12), 30 ppm (low-dose, n = 12), or 430 ppm (higher-dose, n = 12) of lead acetate via dams' milk from postnatal day (PND) 0 to 28. Flow cytometry was used to quantify cell types and cell surface expression of MHC II and CCR7 in hippocampal and whole brain microglia. Non-parametric independent samples median tests were used to test for statistically significant differences between groups. As compared to controls, CCR7 in hippocampal microglia was decreased in the low-dose group, measured as geometric mean fluorescence intensity (GMFI); in the higher-dose group CCR7

Indexed as

AnimalsAnimals, NewbornDown-RegulationFemaleHippocampusHistocompatibility Antigens Class IILactationLead Poisoning, Nervous System, ChildhoodMacrophagesMaleMice, Inbred C57BLMicrogliaOrganometallic CompoundsReceptors, CCR7Time FactorsCcr7 protein, mouseHistocompatibility Antigens Class IIlead acetateOrganometallic CompoundsReceptors, CCR7CCR7Flow cytometryLeadMHC IIMicroglia

Identifiers

PMID31306743
PMCPMC7815484
OpenAlexW2958578958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.