ArticleActa psychiatrica Scandinavica2019
The association between depressive mood and ischemic heart disease: a twin study.
Article in Acta psychiatrica Scandinavica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Genetic perspectives on the comorbidity of anxiety and mood disorders with cardiovascular disease.Nature cardiovascular research · 2026Review
- Triglycerides play a crucial role in the pathway from depression to cardiomyopathy: A mediation Mendelian randomization study.Medicine · 2026Article
- Links Between Psychiatric Disorders and Cardiovascular Diseases.Phenomics (Cham, Switzerland) · 2025Article
- The association of eight-year trajectories in total, cognitive-affective, and somatic depressive symptoms with incident stroke: a 10-year follow-up study using HRS and ELSA cohorts.Frontiers in aging neuroscience · 2025Article
- Association of clinical phenotypes of depression with comorbid conditions, treatment patterns and outcomes: a 10-year region-based cohort study.Translational psychiatry · 2024Observational
- Eight-year total, cognitive-affective, and somatic depressive symptoms trajectories and risks of cardiac events.Translational psychiatry · 2024Article
- Risk of Cardiovascular Disease Hospitalization After Common Psychiatric Disorders: Analyses of Disease Susceptibility and Progression Trajectory in the UK Biobank.Phenomics (Cham, Switzerland) · 2024Article
- High genetic risk for depression as an independent risk factor for mortality in patients referred for coronary angiography.Frontiers in cardiovascular medicine · 2023Article
- Disease trajectories and mortality among individuals diagnosed with depression: a community-based cohort study in UK Biobank.Molecular psychiatry · 2021Article
- The familial and genetic contribution to the association between depression and cardiovascular disease: a twin cohort study.Molecular psychiatry · 2021Article
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7 authors.
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Abstract
objectiveIndividuals with mood disorders have increased risk of cardiovascular disease. The aims of this study were to evaluate if the risk of cardiovascular disease in individuals with mood disorder could be explained by shared genetic and early environmental factors.
methodsWe included 6714 Danish middle and old aged twins from two large population-based studies. Cox proportional hazards regression was used to perform individual-level and intra-pair analyses of the association between self-reported depression symptomatology scores and register-based diagnoses of ischemic heart disease.
resultsHigher depression symptomatology scores (both total, affective, and somatic) were associated with higher incidence of ischemic heart disease after multivariable adjustment in individual-level analyses. In intra-pair analyses, this association was similar but with slightly larger confidence intervals. There was no interaction with gender and no major differences between mono- or dizygotic twins. Within twin pairs, the twin scoring highest on depressive symptoms developed ischemic heart disease more often or earlier than the lower scoring twin. A sensitivity analysis including a 2-year time lag of depression symptomatology to limit the risk of reverse causality showed similar results.
conclusionGenetic factors and early life environment do not seem to explain the association between depressive mood and ischemic heart disease.
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