Evidence map›Paper›PMID 31306250›Full record

ReviewCurrent opinion in psychiatry2019

Gonadal hormone contributions to individual differences in eating disorder risk.

Megan E Mikhail, Kristen M Culbert, Cheryl L Sisk, Kelly L Klump

Abstract readReview
In one paragraph

Review in Current opinion in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
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  3. Review
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  7. Review
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  15. Review
  16. Trait negative affect interacts with ovarian hormones to predict risk for emotional eating.Clinical psychological science : a journal of the Association for Psychological Science · 2021
    Article
  17. Review
  18. Relationship of estrogen synthesis capacity in the brain with obesity and self-control in men and women.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Megan E MikhailDepartment of Psychology, Michigan State University, East Lansing, Michigan.
Kristen M CulbertDepartment of Psychology, University of Nevada, Las Vegas, Nevada.
Cheryl L SiskNeuroscience Program, Michigan State University, East Lansing, Michigan, USA.
Kelly L KlumpDepartment of Psychology, Michigan State University, East Lansing, Michigan.

Funding

A Twin Study of exogenous hormone exposure and risk for binge eatingR01MH111715 · NIMH · MICHIGAN STATE UNIVERSITY · PI KLUMP, KELLY L · 2017 to 2021
$4.0M
NIMH NIH HHS R01 MH111715
6 · The paper itself

Abstract

purpose of reviewFemales experience eating disorders at substantially higher rates than males. Although sociocultural factors have traditionally been thought to underlie this sex disparity, accumulating evidence implicates differential exposure to gonadal hormones early in life. Gonadal hormones also impact within-sex variability in disordered eating, helping to explain why not all women develop an eating disorder, and some men do. We review recent findings regarding these gonadal hormone effects and their implications for the etiology of eating disorders. RECENT

findingsMales are exposed to significantly higher testosterone levels than females perinatally, and this exposure appears to protect against later binge eating in males relative to females. Within-sex, higher estradiol levels among females and higher testosterone levels among males appear to be protective. Progesterone exhibits minimal direct phenotypic effects on disordered eating but appears to counteract the protective effects of estrogen in adult females. Importantly, gonadal hormone effects may be moderated by psychosocial factors. SUMMARY: Evidence suggests that gonadal hormones play a critical role in the etiology of disordered eating. Overall, higher testosterone and estrogen appear to be protective across development. Additional research is needed to identify mechanisms underlying these effects and further explore interactions between hormonal and psychosocial risk.

Indexed as

AnimalsFeeding and Eating DisordersFemaleGonadal HormonesHumansIndividualityMalePregnancySex FactorsGonadal Hormones

Identifiers

PMID31306250
PMCPMC6768704

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.