ArticleRestorative neurology and neuroscience2019
Effect of paired-pulse stimulus parameters on the two phases of short interval intracortical inhibition in the quadriceps muscle group.
Article in Restorative neurology and neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Neuromuscular characteristics of eccentric, concentric and isometric contractions of the knee extensors.European journal of applied physiology · 2025Article
- Shaping corticospinal pathways in virtual reality: effects of task complexity and sensory feedback during mirror therapy in neurologically intact individuals.Journal of neuroengineering and rehabilitation · 2024Article
- How Does Ankle Mechanical Stiffness Change as a Function of Muscle Activation in Standing and During the Late Stance of Walking?IEEE transactions on bio-medical engineering · 2022Article
- Functional Resistance Training to Improve Knee Strength and Function After Acute Anterior Cruciate Ligament Reconstruction: A Case Study.Sports health · 2021Article
- Evaluation of motor cortical excitability using evoked torque responses: A new tool with high reliability.Journal of neuroscience methods · 2021Article
- Use of transcranial magnetic stimulation to assess relaxation rates in unfatigued and fatigued knee-extensor muscles.Experimental brain research · 2021Article
- Effect of conventional transcranial direct current stimulation devices and electrode sizes on motor cortical excitability of the quadriceps muscle.Restorative neurology and neuroscience · 2021Article
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Abstract
backgroundShort interval intracortical inhibition (SICI) is commonly used to assess inhibition in the motor cortex and is known to be affected by the paired-pulse stimulus parameters (i.e., interstimulus interval [ISI], conditioning stimulus intensity [CSI] and test stimulus intensity [TSI]) used during testing. While the effects of stimulus parameters are well-studied in the upper-extremity, evidence in the lower-extremity is lacking.
objectiveTo comprehensively examine the effects of alterations in paired-pulse stimulus parameters on the two phases of SICI in the quadriceps muscle group.
methodsSeventeen adults (8 males, 9 females) volunteered to participate in this study. SICI was examined over a range of CSIs (70-90% active motor threshold [AMT]), TSIs (100-140% AMT), and ISIs (1.0-3.0 ms) using both EMG and torque responses elicited by transcranial magnetic stimulation (TMS).
resultsThe results indicated that SICI at 1.0 ms ISI was best revealed with a CSI of 70% and TSI ≥110% AMT, whereas SICI at 2.5 ms ISI was best revealed with a CSI of 80-90% and a TSI of ≥130% AMT. Unlike upper-extremity muscles, evaluating SICI with a CSI of 70% AMT and an ISI of 1.0 ms produced the greatest inhibition for all TSIs. In general, inhibitory effects were contaminated by facilitatory effects when using a TSI of 100% AMT.
conclusionsThe amount of inhibition was dependent on the stimulation parameters used during testing. A CSI of 70% AMT, ISI of 1.0 ms, and TSI of ≥110% AMT appear to be optimal for measuring SICI in the quadriceps muscle; however, other parameters can be used if careful consideration is given to the described interaction between the parameters.
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