Evidence map›Paper›PMID 31306120›Full record

ArticleJournal of Alzheimer's disease : JAD2019

Measures of Adiposity and Alzheimer's Disease-Related MRI Markers: The Northern Manhattan Study.

Michelle R Caunca, Marialaura Simonetto, Noam Alperin, Mitchell S V Elkind, Ralph L Sacco, Clinton B Wright, Tatjana Rundek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michelle R CauncaDivision of Epidemiology and Population Health Sciences, Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.
Marialaura SimonettoDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Noam AlperinEvelyn F. McKnight Brain Institute, University of Miami, Miami, FL, USA.
Mitchell S V ElkindDepartment of Epidemiology, Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Ralph L SaccoDivision of Epidemiology and Population Health Sciences, Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.
Clinton B WrightNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Tatjana RundekDivision of Epidemiology and Population Health Sciences, Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.

Funding

STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONR01NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 1993 to 2019
$19.2M
Effects of White and Gray Matter Integrity on Cognition in A Multi-Ethnic CohortF30NS103462 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CAUNCA, MICHELLE RAE · 2017 to 2020
$199k
NINDS NIH HHS F30 NS103462NINDS NIH HHS R01 NS029993
6 · The paper itself

Abstract

backgroundAdiposity may increase risk for dementia and Alzheimer's disease (AD), but mechanisms are unclear.

objectiveTo examine associations between measures of adiposity with AD-signature region cortical thickness and hippocampal volume.

methodsWe used data from the Northern Manhattan Study, a clinically stroke-free cohort of mostly Hispanic participants. Exposures of interest included body mass index (BMI), waist-hip-ratio (WHR), waist circumference (WC), and adiponectin concentration, measured at study entry. AD-signature region cortical thickness and hippocampal volume were obtained using Freesurfer. We estimated associations using multivariable linear regression, adjusting for sociodemographics and health behaviors. We re-examined estimates after adjustment for APOEɛ4 allele status or carotid intima-media thickness (cIMT), among those cognitively unimpaired, and after weighting for the inverse probability of selection into the MRI sub-study. We also repeated analyses for cortical thickness in non-AD signature regions.

resultsThe sample (N = 947, 63% women, 66% Hispanic/Latino, 26% obese) had a mean (SD) age = 63 (8) years. Greater BMI and WC (both z-scored) were associated with thinner AD-signature region cortex (also z-scored) (BMI: β [95% CI] = -0.09 [-0.18, -0.01], WC: β [95% CI] = -0.11 [-0.20, -0.02]). We did not find evidence that adiposity was related to hippocampal volume. Results were consistent after adjustment for APOEɛ4 allele status or cIMT, after weighting for selection, among those cognitively unimpaired, and for non-AD signature region cortical thickness.

conclusionGreater BMI and WC were related to cortical thinning within and outside the AD-signature region, suggesting a global effect not specific to AD.

Indexed as

Mental Status and Dementia TestsAdiposityAgedAlzheimer DiseaseCohort StudiesCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNew York CityRisk FactorsWaist CircumferenceAdipositybrain agingepidemiologyneuroimagingstructural MRI

Identifiers

PMID31306120
PMCPMC7212498

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.