Evidence map›Paper›PMID 31306081›Full record

ReviewGut microbes2020

Mechanisms and consequences of gut commensal translocation in chronic diseases.

Rebecca L Fine, Silvio Manfredo Vieira, Michael S Gilmore, Martin A Kriegel

Open access · goldAbstract readReview
In one paragraph

Review in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rebecca L FineDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Silvio Manfredo VieiraDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8036-4223
Michael S GilmoreDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Martin A KriegelDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Yale University · USMassachusetts Eye and Ear Infirmary · US

Funding

Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1M
Renal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI ARONSON, PETER S. · 2008 to 2022
$16.8M
INTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007019 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, David G. Schatz · 1985 to 2026
$14.4M
TRAINING PROGRAM IN INVESTIGATIVE GASTROENTEROLOGYT32DK007017 · NIDDK · YALE UNIVERSITY · PI Fred Sanford Gorelick, Liza Konnikova · 1986 to 2026
$7.1M
Yale Rheumatic Diseases Research Core CenterP30AR053495 · NIAMS · YALE UNIVERSITY · PI HABERMAN, ANN M · 2007 to 2017
$7.0M
Human Gut Commensal Cross-reactivity in Antiphospholipid SyndromeR01AI118855 · NIAID · YALE UNIVERSITY · PI KRIEGEL, MARTIN A., MEFFRE, ERIC · 2015 to 2019
$2.1M
Role of Gender-associated Microbiota in Organ-specific AutoimmunityK08AI095318 · NIAID · YALE UNIVERSITY · PI KRIEGEL, MARTIN A. · 2011 to 2015
$682k
NIAID NIH HHS K08 AI095318NIAID NIH HHS R01 AI118855NIAID NIH HHS T32 AI007019NIAMS NIH HHS P30 AR053495NIDDK NIH HHS P30 DK034989NIDDK NIH HHS P30 DK079310NIDDK NIH HHS T32 DK007017
6 · The paper itself

Abstract

Humans and other mammalian hosts have evolved mechanisms to control the bacteria colonizing their mucosal barriers to prevent invasion. While the breach of barriers by bacteria typically leads to overt infection, increasing evidence supports a role for translocation of commensal bacteria across an impaired gut barrier to extraintestinal sites in the pathogenesis of autoimmune and other chronic, non-infectious diseases. Whether gut commensal translocation is a cause or consequence of the disease is incompletely defined. Here we discuss factors that lead to translocation of live bacteria across the gut barrier. We expand upon our recently published demonstration that translocation of the gut pathobiont

Indexed as

Autoimmune DiseasesAnimalsAutoimmunityBacteriaBacterial TranslocationChronic DiseaseEnterococcusGastrointestinal MicrobiomeHumansIntestinal MucosaMicrobiotaSymbiosisautoimmune liver diseaseautoimmunitybacterial translocationenterococcusgut lymphatic barrierGut vascular barrierintestinal permeabilitylupusmicrobiotatight junctionsTLR7vancomycin resistance

Identifiers

PMID31306081
PMCPMC7053960
OpenAlexW2957850488

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.