Evidence map›Paper›PMID 31306061›Full record

ArticleCell cycle (Georgetown, Tex.)2019

Switching of INCENP paralogs controls transitions in mitotic chromosomal passenger complex functions.

Haiyang Feng, Martina Raasholm, Alexandra Moosmann, Coen Campsteijn, Eric M Thompson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Haiyang Fenga Sars International Centre for Marine Molecular Biology, University of Bergen , Bergen , Norway.
Martina Raasholma Sars International Centre for Marine Molecular Biology, University of Bergen , Bergen , Norway.
Alexandra Moosmanna Sars International Centre for Marine Molecular Biology, University of Bergen , Bergen , Norway.
Coen Campsteijna Sars International Centre for Marine Molecular Biology, University of Bergen , Bergen , Norway.ORCID 0000-0001-5286-1521
Eric M Thompsona Sars International Centre for Marine Molecular Biology, University of Bergen , Bergen , Norway.ORCID 0000-0002-3756-9036
University of Bergen · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A single inner centromere protein (INCENP) found throughout eukaryotes modulates Aurora B kinase activity and chromosomal passenger complex (CPC) localization, which is essential for timely mitotic progression. It has been proposed that INCENP might act as a rheostat to regulate Aurora B activity through mitosis, with successively higher activity threshold levels for chromosome alignment, the spindle checkpoint, anaphase spindle transfer and finally spindle elongation and cytokinesis. It remains mechanistically unclear how this would be achieved. Here, we reveal that the urochordate,

Indexed as

Aurora Kinase BCDC2 Protein KinaseCell Cycle ProteinsChromosomal Proteins, Non-HistoneChromosomesChromosome SegregationCytokinesisHumansKinetochoresMitosisPhosphorylationPlanktonPolo-Like Kinase 1Protein Serine-Threonine KinasesProto-Oncogene ProteinsSpindle ApparatusAURKB protein, humanAurora Kinase BCDC2 Protein KinaseCDK1 protein, humanCell Cycle ProteinsChromosomal Proteins, Non-HistoneINCENP protein, humanPolo-Like Kinase 1Protein Serine-Threonine KinasesProto-Oncogene ProteinsabscissionAurora B kinasecytokinesisInner Centromere Protein (INCENP)kinetochoretunicate

Identifiers

PMID31306061
PMCPMC6681789
OpenAlexW2957118950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.