ArticleACS infectious diseases2019
Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner.
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In one paragraph
Article in ACS infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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0cells of the map it votes in
43citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 72 citations in OpenAlex.
- Targeting Picornavirus Nonstructural 2C Protein: Structure, Function, and Antiviral Discovery.ACS infectious diseases · 2026Review
- Coxsackievirus B escapes antiviral CD8Science advances · 2026Article
- Rational design and in vivo validation of capsid inhibitors for enterovirus D68.Nature communications · 2026Article
- Respiratory enterovirus D68: virology, clinical surveillance, host-pathogen interactions, and therapeutic prospects.Frontiers in cellular and infection microbiology · 2026Review
- Markers of neuroinflammation in the CSF of patients with difficult to treat psychiatric disease.Frontiers in psychiatry · 2026Article
- Sialic Acid-Containing Glycolipids Extend the Receptor Repertoire of Enterovirus-D68.ACS infectious diseases · 2025Article
- Echovirus serotype 11 induced sepsis in a young female patient with multiple sclerosis treated with anti-CD20 monoclonal antibody ocrelizumab.Infection · 2025Article
- Advances in the Treatment of Enterovirus-D68 and Rhinovirus Respiratory Infections.Infectious disease reports · 2025Review
- Toward Personalized Medicine: The Effect of Treatment of Chronic Enterovirus Diarrhea in an Immunocompromised Patient and the Correlation With In Vitro Models.Open forum infectious diseases · 2025Article
- Emerging Therapeutics in the Fight Against EV-D68: A Review of Current Strategies.Influenza and other respiratory viruses · 2024Review
- Fluoxetine Successfully Treats Intracranial Enterovirus E18 Infection in a Patient with CD79a Deficiency Arising from Segmental Uniparental Disomy of Chromosome 19.Journal of clinical immunology · 2024Article
- Severe enterovirus infections in patients with immune-mediated inflammatory diseases receiving anti-CD20 monoclonal antibodies.RMD open · 2024Article
- Picornavirus 2C proteins: structure-function relationships and interactions with host factors.Frontiers in cellular and infection microbiology · 2024Review
- Role of protein Post-translational modifications in enterovirus infection.Frontiers in microbiology · 2024Review
- Insights into enterovirus a-71 antiviral development: from natural sources to synthetic nanoparticles.Archives of microbiology · 2023Review
- Direct-Acting Antivirals and Host-Targeting Approaches against Enterovirus B Infections: Recent Advances.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Drug Repositioning for Hand, Foot, and Mouth Disease.Viruses · 2022Review
- Selective serotonin reuptake inhibitor (SSRI) antidepressants reduce COVID-19 infection: prospects for use.European journal of clinical pharmacology · 2022Review
- Enterovirus A71 antivirals: Past, present, and future.Acta pharmaceutica Sinica. B · 2022Article
- Compassionate-use pocapavir and immunoglobulin therapy for treatment of rituximab-associated enterovirus meningoencephalitis.Journal of neurovirology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 4 countries.
Lisa BauerVirology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht 3584CL , The Netherlands.
Roberto ManganaroSchool of Pharmacy and Pharmaceutical Sciences , Cardiff University , King Edward VII Avenue , Cardiff CF10 3NB , United Kingdom.
Birgit ZonsicsSchool of Pharmacy and Pharmaceutical Sciences , Cardiff University , King Edward VII Avenue , Cardiff CF10 3NB , United Kingdom.
Jeroen R P M StratingVirology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht 3584CL , The Netherlands.
Priscila El KazziArchitecture et Fonction des Macromolécules Biologiques, UMR 6098 Centre National de la Recherche Scientifique, Université de la Méditerranée and Université de Provence , Aix-Marseille Université , Case 925, 163 Avenue de Luminy , Marseille 3288 CEDEX 9 , France.
Moira Lorenzo LopezSchool of Pharmacy and Pharmaceutical Sciences , Cardiff University , King Edward VII Avenue , Cardiff CF10 3NB , United Kingdom.
Rachel UlfertsVirology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht 3584CL , The Netherlands.
Clara van HoeyDepartment of Pharmaceutical Chemistry, Faculty of Life Sciences , University of Vienna , Althanstraße 14 , Vienna A-1090 , Austria.
Maria J MatéArchitecture et Fonction des Macromolécules Biologiques, UMR 6098 Centre National de la Recherche Scientifique, Université de la Méditerranée and Université de Provence , Aix-Marseille Université , Case 925, 163 Avenue de Luminy , Marseille 3288 CEDEX 9 , France.
Thierry LangerDepartment of Pharmaceutical Chemistry, Faculty of Life Sciences , University of Vienna , Althanstraße 14 , Vienna A-1090 , Austria.ORCID 0000-0002-5242-1240
Bruno CoutardArchitecture et Fonction des Macromolécules Biologiques, UMR 6098 Centre National de la Recherche Scientifique, Université de la Méditerranée and Université de Provence , Aix-Marseille Université , Case 925, 163 Avenue de Luminy , Marseille 3288 CEDEX 9 , France.
Andrea BrancaleSchool of Pharmacy and Pharmaceutical Sciences , Cardiff University , King Edward VII Avenue , Cardiff CF10 3NB , United Kingdom.ORCID 0000-0002-9728-3419
Frank J M van KuppeveldVirology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht 3584CL , The Netherlands.ORCID 0000-0001-5800-749X
Cardiff University · GBUtrecht University · NLAix-Marseille Université · FRUniversity of Vienna · ATInserm · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enteroviruses (family
Indexed as
Carrier ProteinsDrug RepositioningEnterovirus B, HumanEnterovirus D, HumanFluoxetineHeLa CellsHumansModels, MolecularMolecular StructureMutationProtein BindingProtein ConformationStructural Homology, ProteinViral Nonstructural ProteinsVirus Replication2C protein, viralCarrier ProteinsFluoxetineViral Nonstructural Proteinsantiviraldrug repurposingenterovirusesmolecular modelingvirus replication
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.