Evidence map›Paper›PMID 31305880›Full record

ArticleAmerican journal of clinical pathology2019

Assessment of The Bethesda System for Reporting Thyroid Cytopathology.

Jennifer L Sauter, Heidi Lehrke, Xiaotun Zhang, Osamah T Al Badri, Rene Rodriguez-Gutierrez, Danae A Delivanis, Naykky Singh Ospina, Diane Donegan, Oksana Hamidi, Nicole Iñiguez-Ariza and 10 more

Abstract read
In one paragraph

Article in American journal of clinical pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
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  5. Article
  6. Article
  7. Article
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  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Thyroid Nodule Evaluation and Management in Older Adults: A Review of Practical Considerations for Clinical Endocrinologists.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2021
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jennifer L SauterDivision of Anatomic Pathology, Mayo Clinic, Rochester, MN.
Heidi LehrkeDivision of Anatomic Pathology, Mayo Clinic, Rochester, MN.
Xiaotun ZhangDivision of Anatomic Pathology, Mayo Clinic, Rochester, MN.
Osamah T Al BadriDivision of Anatomic Pathology, Mayo Clinic, Rochester, MN.
Rene Rodriguez-GutierrezDivision of Endocrinology, Mayo Clinic, Rochester, MN.
Danae A DelivanisDivision of Endocrinology, Mayo Clinic, Rochester, MN.
Naykky Singh OspinaDivision of Endocrinology, Mayo Clinic, Rochester, MN.
Diane DoneganDivision of Endocrinology, Mayo Clinic, Rochester, MN.
Oksana HamidiDivision of Endocrinology, Mayo Clinic, Rochester, MN.
Nicole Iñiguez-ArizaDivision of Endocrinology, Mayo Clinic, Rochester, MN.
Anu SharmaDivision of Endocrinology, Mayo Clinic, Rochester, MN.
Nana Esi N KittahDivision of Endocrinology, Mayo Clinic, Rochester, MN.
Shrikant U TamhaneDivision of Endocrinology, Mayo Clinic, Rochester, MN.
Maria D Hurtado AndradeDivision of Endocrinology, Mayo Clinic, Rochester, MN.
Anupam KotwalDivision of Endocrinology, Mayo Clinic, Rochester, MN.
Sarah M JenkinsDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN.
Grant SpearsDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN.
Michael RiveraDivision of Anatomic Pathology, Mayo Clinic, Rochester, MN.
Diana S DeanDivision of Endocrinology, Mayo Clinic, Rochester, MN.
Michael R HenryDivision of Anatomic Pathology, Mayo Clinic, Rochester, MN.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

objectivesLong-term follow-up is important for determining performance characteristics of thyroid fine-needle aspiration (FNA).

methodsHistologic or 3 or more years of clinical follow-up was used to calculate performance characteristics of thyroid FNA before and after implementation of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). The impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) classification was also investigated.

resultsFollow-up was obtained for 1,277/1,134 and 1,616/1,393 aspirates/patients (median clinical follow-up, 9.9 and 4.4 years, pre- and post-TBSRTC, respectively). Nondiagnostic, suspicious for follicular neoplasm, and suspicious for malignancy (SFM) diagnoses decreased and benign diagnoses increased post-TBSRTC, while atypical rate remained less than 1%. Negative predictive value for benign nodules and positive predictive value (PPV) for SFM increased significantly. Eleven nodules were reclassified as NIFTP, slightly decreasing PPV/risk of malignancy (ROM).

conclusionsAppropriate ROM for thyroid FNA can be achieved through application of TBSRTC terminology with minimal use of atypical category.

Indexed as

Adenocarcinoma, FollicularAdultAgedBiopsy, Fine-NeedleFemaleFollow-Up StudiesHumansMaleMiddle AgedThyroid Cancer, PapillaryThyroid GlandThyroid NeoplasmsAtypia of undetermined significance/follicular lesion of undetermined significanceBethesdaCytopathologyFine-needle aspirationFNAFollicular neoplasm/suspicious for follicular neoplasmNoninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)Papillary thyroid carcinomaRisk of malignancyThyroid

Identifiers

PMID31305880
PMCPMC8204148

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.