ArticleMedicine2019
Effects of exercise on the levels of BDNF and executive function in adolescents: A protocol for systematic review and meta-analysis.
Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- The Effects of Exercise on BDNF Levels in Adolescents: A Systematic Review with Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Controlled Hypoxia Acutely Prevents Physical Inactivity-Induced Peripheral BDNF Decline.International journal of molecular sciences · 2024Trial
- Physical activity and improvement of physiological parameters by training.Frontiers in sports and active living · 2026Review
- Associations between objectively measured physical activity intensities and executive function in preschool children: a cross-sectional study.Frontiers in psychiatry · 2026Article
- Sculpting the developing brain: a review of neural mechanisms linking physical activity to executive function and emotion regulation in youth.Frontiers in psychology · 2026Review
- Exercise as Modulator of Brain-Derived Neurotrophic Factor in Adolescents: A Systematic Review of Randomized Controlled Trials.Sports (Basel, Switzerland) · 2025Review
- First establishment of population-specific brain volume reference standards for Chinese children and adolescents: an AI-based segmentation study.Frontiers in pediatrics · 2025Article
- Impact of Exercise Intensity on Cerebral BDNF Levels: Role of FNDC5/Irisin.International journal of molecular sciences · 2024Article
- Effectiveness of a Computerized Home-Based Cognitive Stimulation Program for Treating Cancer-Related Cognitive Impairment.International journal of environmental research and public health · 2023Article
- Article
- Association of the Brain-derived Neurotrophic Factor Val66Met Polymorphism with Body Mass Index, Fasting Glucose Levels and Lipid Status in Adolescents.Balkan journal of medical genetics : BJMG · 2020Article
- The Contribution of Physical Exercise to Brain Resilience.Frontiers in behavioral neuroscience · 2020Review
- Physical Activity and Brain Health.Genes · 2019Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backogroundEvidence available in the literature suggests that physical exercise increases the release of brain-derived neurotrophic factor (BDNF) in humans and may possibly be related to improvements in executive function. However, studies of this phenomenon in adolescents are still scarce. The objective of this work is to describe the protocol for a systematic review (SR) and meta-analysis of interventional studies aiming to determine the effect of physical exercise on BDNF levels and executive function in adolescents.
methodsThis protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) and by the Cochrane Handbook of Systematic Reviews of Interventions. The databases to be searched are PubMed, EMBASE, Scopus, ScienceDirect, Web of Science, SPORTDiscus, the Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL. Interventional studies conducted on adolescents with different exercise protocols and evaluations of BDNF levels and executive function in pre- and post-intervention periods will be included in the systematic review. The characteristics of the studies, participants, and main results will be described, then the evaluation of the risk of biases and the level of evidence obtained by the protocol will be assessed. The selection of studies, data extraction, and evaluation of the methodological quality will be performed by 2 experienced reviewers independently.
conclusionThe systematic review will present the effects of the practice of physical exercises on the BDNF and executive function levels. The results will strengthen the interventions with the focus on the brain health of adolescents through general orientations and the evidences described shall direct future research. PROSPERO REGISTRATION NUMBER: CRD42018110683.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.