Observational studyAIDS (London, England)2019
Frailty in medically complex individuals with chronic HIV.
Observational study in AIDS (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 26 citations in OpenAlex.
- Exploring frailty in the context of HIV and aging in Kazakhstan: findings from a pilot cross-sectional study.BMC public health · 2026Article
- Prevalence and risk factors of cognitive frailty in people with HIV.AIDS (London, England) · 2026Observational
- Frailty among adult people living with HIV in Tanzania: a single-centred hospital-based cross-sectional study.BMJ public health · 2026Article
- "As I Grew Older, My Life Got Better": Conceptions of Successful Aging among Older Women Living with or at Risk of HIV.AIDS and behavior · 2024Article
- Frailty-Related Factors among Women Living with and without HIV Aged 40 Years and Older. The Women's Interagency HIV Study.The Journal of frailty & aging · 2024Article
- Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management.Nature reviews. Neurology · 2023Review
- Convenience, efficacy, safety, and durability of INSTI-based antiretroviral therapies: evidence from the Italian MaSTER cohort.European journal of medical research · 2023Article
- Machine Learning Approaches to Understand Cognitive Phenotypes in People With HIV.The Journal of infectious diseases · 2023Article
- Twelve-year neurocognitive decline in HIV is associated with comorbidities, not age: a CHARTER study.Brain : a journal of neurology · 2023Article
- The Structural and Functional Correlates of Frailty in Persons With Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Associations between drug and alcohol use, smoking, and frailty among people with HIV across the United States in the current era of antiretroviral treatment.Drug and alcohol dependence · 2022Article
- Prevalence of Frailty and Prefrailty in People With Human Immunodeficiency Virus Aged 50 or Older: A Systematic Review and Meta-Analysis.Open forum infectious diseases · 2022Article
- Higher Comorbidity Burden Predicts Worsening Neurocognitive Trajectories in People with Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Multimorbidity networks associated with frailty among middle-aged and older people with HIV.AIDS (London, England) · 2021Article
- Frailty and HIV: Moving from Characterization to Intervention.Current HIV/AIDS reports · 2021Review
- Assessment, prevalence, and correlates of frailty among middle-aged adults with HIV in rural Uganda.Journal of neurovirology · 2021Article
- Ensemble machine learning classification of daily living abilities among older people with HIV.EClinicalMedicine · 2021Article
- Cost-Effectiveness Analysis Combining Medical and Mental Health Services for Older Adults with HIV in New York City.Atlantic economic journal : AEJ · 2021Article
- Neurocognitive Trajectories After 72 Weeks of First-Line Anti-retroviral Therapy in Vietnamese Adults With HIV-HCV Co-infection.Frontiers in neurology · 2021Article
- Deep Phenotyping of HIV Neurocognitive Complications Among Individuals Residing in High-Income Countries.Current topics in behavioral neurosciences · 2021Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
Abstract
objectivesMultimorbidity and frailty are consequences of aging with HIV, yet not everyone with medical disease is frail. Our objective was to identify factors associated with frailty in a multimorbid HIV-infected cohort.
designAnalysis of a prospective, observational, longitudinal cohort.
methodsThree hundred and thirty-two participants in the medically advanced National NeuroAIDS Tissue Consortium (NNTC) study were categorized as frail, prefrail, or robust with the Fried Frailty Index. A series of logistic regression analyses (first univariate, then multivariable) were conducted to determine whether medical comorbidities, immunologic and virologic parameters, and/or neuropsychiatric variables predicted increased odds of frailty.
resultsThe mean number of medical comorbidities per participant was 2.7, mean CD4 T-cell count was 530 cells/μl, and 77% had undetectable HIV RNA in blood. Twenty-two percent were frail, 55% prefrail, and 23% robust. Significant predictors of frailty in multivariable analysis were cognitive diagnosis rendered by Frascati criteria, depressive symptoms, diabetes mellitus, chronic obstructive pulmonary disease (COPD), and sex. Men were less likely to be frail than women. Higher odds of frailty were seen with: symptomatic, but not asymptomatic, cognitive impairment (compared with cognitive normals); more depressive symptoms; diabetes mellitus; and COPD.
conclusionNeuropsychiatric illness increased odds of being frail on a predominantly physical/motoric measure, but only when symptomatic. Lack of association with asymptomatic impairment may reflect the importance of functional limitation to frailty, or possibly a unique resilience phenotype. Understanding why sex and symptomatic neuropsychiatric illness are associated with frailty will be important in managing HIV-associated morbidity in aging populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.