ArticleAlzheimer disease and associated disorders
Type 2 Diabetes Interacts With Alzheimer Disease Risk Factors to Predict Functional Decline.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- Article
- Association of glycogen synthase kinase-3β with cognitive impairment in type 2 diabetes patients: a six-year follow-up study.Frontiers in endocrinology · 2024Article
- Type 2 Diabetes Moderates the Association Between Amyloid and 1-Year Change in Everyday Functioning in Older Veterans.Journal of Alzheimer's disease : JAD · 2024Article
- Prenatal alcohol exposure causes persistent microglial activation and age- and sex- specific effects on cognition and metabolic outcomes in an Alzheimer's Disease mouse model.The American journal of drug and alcohol abuse · 2023Article
- Neurotransmitters in Type 2 Diabetes and the Control of Systemic and Central Energy Balance.Metabolites · 2023Review
- Linking Diabetes to Alzheimer's Disease: Potential Roles of Glucose Metabolism and Alpha-Glucosidase.Current neuropharmacology · 2023Review
- Increased regional white matter hyperintensity volume in objectively-defined subtle cognitive decline and mild cognitive impairment.Neurobiology of aging · 2022Article
- Tau levels are higher in objective subtle cognitive decline but not subjective memory complaint.Alzheimer's research & therapy · 2022Article
- Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline.International journal of molecular sciences · 2022Review
- Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents.Aging and disease · 2022Review
- Altered cortical thickness, degree centrality, and functional connectivity in middle-age type 2 diabetes mellitus.Frontiers in neurology · 2022Article
- Regional hyperperfusion in older adults with objectively-defined subtle cognitive decline.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Crosstalk between Gut and Brain in Alzheimer's Disease: The Role of Gut Microbiota Modulation Strategies.Nutrients · 2021Review
- Secondary Prevention of Dementia: Combining Risk Factors and Scalable Screening Technology.Frontiers in neurology · 2021Review
- Arterial Stiffening Moderates the Relationship Between Type-2 Diabetes Mellitus and White Matter Hyperintensity Burden in Older Adults With Mild Cognitive Impairment.Frontiers in aging neuroscience · 2021Article
- Objective subtle cognitive decline and plasma phosphorylated tau181: Early markers of Alzheimer's disease-related declines.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Influence of the Mediterranean and Ketogenic Diets on Cognitive Status and Decline: A Narrative Review.Nutrients · 2020Review
- Showing NAFLD, as a key connector disease between Alzheimer's disease and diabetes via analysis of systems biology.Gastroenterology and hepatology from bed to bench · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectiveThe current study examined the interactive effect of type 2 diabetes and Alzheimer disease (AD) risk factors on the rate of functional decline in cognitively normal participants from the Alzheimer's Disease Neuroimaging Initiative.
methodsParticipants underwent annual assessments that included the Functional Activities Questionnaire, an informant-rated measure of everyday functioning. Multilevel modeling, controlling for demographic variables and ischemic risk, examined the interactive effects of diabetes status (diabetes, n=69; no diabetes, n=744) and AD risk factors in the prediction of 5-year longitudinal change in everyday functioning. One model was run for each AD risk factor, including: objectively-defined subtle cognitive decline (Obj-SCD), and genetic susceptibility [apolipoprotein E ε4 (APOE ε4) as well as cerebrospinal fluid β-amyloid (Aβ), total tau (tau), and hyperphosphorylated tau (p-tau).
resultsThe 3-way diabetes×AD risk factor×time interaction predicted increased rates of functional decline in models that examined Obj-SCD, APOE ε4, tau, and p-tau positivity, but not Aβ positivity.
conclusionsParticipants with both diabetes and at least 1 AD risk factor (ie, Obj-SCD, APOE ε4, tau, and p-tau positivity) demonstrated faster functional decline compared with those without both risk factors (diabetes or AD). These findings have implications for early identification of, and perhaps earlier intervention for, diabetic individuals at risk for future functional difficulty.
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