ArticleAlzheimer disease and associated disorders
Association of TDP-43 Pathology With Domain-specific Literacy in Older Persons.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- APOE ε4 and Decline in Health and Financial Literacy in Advanced Age.Journal of the American Geriatrics Society · 2026Article
- Differences and overlaps in TDP-43 pathology of 'pure' LATE-NC compared to LATE-NC coexisting with Alzheimer's disease.Acta neuropathologica · 2025Article
- Exploring Health and Financial Literacy in Patients With Peripheral Nerve Injury: A Cross-Sectional Analysis of Patients Treated Surgically.Journal of hand surgery global online · 2025Article
- Differential correlations of changes in in vivo neuroimaging markers of hippocampal volume and arteriolosclerosis with declining financial and health literacy in old age.Brain imaging and behavior · 2024Article
- The Relationship of MRI-Derived Alzheimer's and Cerebrovascular-Related Signatures With Level of and Change in Health and Financial Literacy.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Article
- Limbic-predominant age-related TDP43 encephalopathy (LATE) neuropathological change in neurodegenerative diseases.Nature reviews. Neurology · 2023Review
- Well-Being and Aging-Related Decline in Financial and Health Literacy in Advanced Age.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Understanding the role of financial health literacy in midlife and old age: A scoping review.Health & social care in the community · 2022Article
- Alzheimer's Disease Neuropathological Comorbidities are Common in the Younger-Old.Journal of Alzheimer's disease : JAD · 2021Article
- Distinct molecular patterns of TDP-43 pathology in Alzheimer's disease: relationship with clinical phenotypes.Acta neuropathologica communications · 2020Article
- Assessing numerical reasoning provides insight into financial literacy.Applied neuropsychology. AdultArticle
- Limbic-predominant Age-related TDP-43 Encephalopathy and Distinct Longitudinal Profiles of Domain-specific Literacy.Alzheimer disease and associated disordersArticle
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Authors and funding
6 authors.
Funding
Abstract
backgroundLow health and financial literacy may be an early behavioral manifestation of cognitive impairment, dementia, and accumulating Alzheimer pathology. However, there are limited studies investigating the behavioral features associated with hyperphosphorylated transactive response DNA-binding protein-43 (TDP-43), a common age-related pathology, and even fewer studies investigating the neurobiological basis underlying low literacy in aging.
objectiveTo test the hypothesis that TDP-43 pathology is associated with lower literacy. MATERIALS AND
methodsData came from 293 community-based older persons who were enrolled in 2 ongoing studies of aging. Participants completed literacy and cognitive assessments, consented to brain donation, and underwent detailed neuropathologic evaluation for Alzheimer disease (AD) and TDP-43. Linear regression models assessed the association of TDP-43 with literacy after adjusting for demographics, and AD pathology. Posthoc pairwise comparisons examined whether the level of literacy differed by TDP-43 stage.
resultsTDP-43 pathology was associated with lower literacy (estimate=-3.16; SE=0.86; P<0.001), above and beyond demographics and AD pathology, and this association persisted even after additionally adjusting for global cognition (estimate=-1.53; SE=0.74; P=0.038). Further, literacy was lower among persons with neocortical TDP-43 pathology compared with those without TDP-43 pathology.
conclusionsTDP-43 pathology is associated with lower health and financial literacy in old age, above and beyond AD pathology.
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