ArticleThe Journal of general virology2019
Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cells.
Article in The Journal of general virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53 citing papers in PubMed, 56 citations in OpenAlex.
- Genetic evolution, phylodynamics, geographic spread of H9N2 avian influenza viruses in China from 2014 to 2025: an increasing potential zoonotic risk.Emerging microbes & infections · 2026Article
- Global evolutionary landscape of H11 avian influenza and initial isolates identified in Xinjiang, China.Emerging microbes & infections · 2026Article
- Article
- Genetic and Pathogenicity Studies of Avian Influenza (H9N2) Virus Isolated from Chickens in Jiangsu Province, China, in 2025.Microorganisms · 2026Article
- Emergence of a novel H4N6 avian influenza virus with mammalian adaptation isolated from migratory birds in Zhejiang Province, China, 2024.Virologica Sinica · 2026Article
- Molecular Characterization of Highly Pathogenic Avian Influenza H5N1 Viruses Circulating in Bulgaria During 2024-2025: Evidence for Hidden Circulation and Zoonotic Risk Markers.International journal of molecular sciences · 2026Article
- Characterization of H5N1 high pathogenicity avian influenza virus belonging to clade 2.3.4.4b isolated from Ezo red fox in Japan in a mouse model.Microbiology spectrum · 2026Article
- Molecular epidemiological characteristics of H9N2 subtype avian influenza virus in the external environment of western Zhejiang, China, 2014-2025.Frontiers in public health · 2026Article
- Molecular Characterization of an H3N2 Canine Influenza Virus Isolated from a Dog in Jiangsu, China, in 2025.Veterinary sciences · 2025Article
- Phylogenetic Analyses and Biological Characterization of H9N2 Avian Influenza Virus Isolated from Chickens in China from 2022 to 2023.Microorganisms · 2025Article
- Evaluation of global distribution, genetic evolution, and mammalian infectivity and pathogenicity of H13 and H16 avian influenza viruses.Emerging microbes & infections · 2025Article
- Phylogenetic and Molecular Characterization of a Novel Reassortant High-Pathogenicity Avian Influenza A (H7N6) Virus Detected in New Zealand Poultry.International journal of molecular sciences · 2025Article
- An emerging PB2-627 polymorphism increases the zoonotic risk of avian influenza virus by overcoming ANP32 host restriction in mammalian and avian hosts.Journal of virology · 2025Article
- Pathogenicity, transmissibility, and receptor binding of a human-isolated influenza A (H10N5) virus.mBio · 2025Article
- Prevalence of Avian Influenza Viruses and Biomolecular Analysis of H9N2 Subtype in Live Poultry Markets from 2021 to 2023 in Changsha, China.Food and environmental virology · 2025Article
- Gut microbiota-derived isovaleric acid ameliorates influenza virus infection via gut-lung axis.NPJ biofilms and microbiomes · 2025Article
- Avian influenza overview March-June 2025.EFSA journal. European Food Safety Authority · 2025Article
- Exploring Avian Influenza Viruses in Yakutia-The Largest Breeding Habitat of Wild Migratory Birds in Northeastern Siberia.Viruses · 2025Article
- Machine learning assessment of zoonotic potential in avian influenza viruses using PB2 segment.BMC genomics · 2025Article
- Diversity of the H9N2 Avian Influenza Virus in Shandong Province, China.Transboundary and emerging diseases · 2025Article
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adaptation of PB2 protein is important for the establishment of avian influenza viruses in mammalian hosts. Here, we identify I292V as the prevalent mutation in PB2 of circulating avian H9N2 and pandemic H1N1 viruses. The same dominant PB2 mutation is also found in most human isolates of emergent avian H7N9 and H10N8 viruses. In human cells, PB2-292V in H9N2 virus has the combined ability of conferring higher viral polymerase activity and stronger attenuation of IFN-β induction than that of its predecessor PB2-292I. IFN-β attenuation is accompanied by higher binding affinity of PB2-292V for host mitochondrial antiviral signalling protein, an important intermediary protein in the induction of IFN-β. In the mouse
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