Evidence map›Paper›PMID 31305157›Full record

ArticleBrain injury2019

Elevated cerebrospinal fluid concentrations of N-acetylaspartate correlate with poor outcome in a pilot study of severe brain trauma.

Nicole D Osier, Melody Ziari, Ava M Puccio, Samuel Poloyac, David O Okonkwo, Margaret B Minnigh, Sue R Beers, Yvette P Conley

Open access · greenAbstract read
In one paragraph

Article in Brain injury, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nicole D Osiera School of Nursing, University of Texas at Austin , Austin , Texas , USA.
Melody Ziaric College of Natural Sciences, University of Texas at Austin , Austin , Texas , USA.
Ava M Pucciod Department of Neurological Surgery, University of Pittsburgh , Pittsburgh , Pennsylvania , USA.
Samuel Poloyace School of Pharmacy, University of Pittsburgh , Pittsburgh , Pennsylvania , USA.
David O Okonkwod Department of Neurological Surgery, University of Pittsburgh , Pittsburgh , Pennsylvania , USA.
Margaret B Minnighe School of Pharmacy, University of Pittsburgh , Pittsburgh , Pennsylvania , USA.
Sue R Beersf Department of Psychiatry, University of Pittsburgh , Pittsburgh , Pennsylvania , USA.
Yvette P Conleyg School of Nursing, University of Pittsburgh , Pittsburgh , Pennsylvania , USA.
University of Pittsburgh · USNeurological Surgery · USThe University of Texas at Austin · US

Funding

UNIVERSITY OF PITTSBURGH BRAIN TRAUMA RESEARCH CENTERP50NS030318 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DIXON, C EDWARD · 1995 to 2007
$8.9M
Genomic Variability and Symptomatology After Traumatic Brain InjuryR01NR013342 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONLEY, YVETTE P · 2011 to 2013
$1.2M
Mitochrondrial Genetics of Recovery After Brain InjuryR01NR008424 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONLEY, YVETTE P · 2005 to 2008
$1.0M
Transcriptomics in Traumatic Brain Injury: Relationship to Brain Oxygenation and OutcomesR00NR013176 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PUCCIO, AVA M. · 2014 to 2016
$724k
NINDS NIH HHS P50 NS030318NINR NIH HHS R00 NR013176NINR NIH HHS R01 NR008424NINR NIH HHS R01 NR013342
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdolescentAdultAgedAspartic AcidBrain Injuries, TraumaticDisability EvaluationFemaleGlasgow Coma ScaleGlasgow Outcome ScaleHumansMaleMiddle AgedPilot ProjectsPredictive Value of TestsPrognosisProspective StudiesAspartic AcidN-acetylaspartatebiomarkerbrain traumaN-acetylaspartate (NAA)severe TBITraumatic brain injury (TBI)

Identifiers

PMID31305157
PMCPMC6675639
OpenAlexW2962332150

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.