ArticleJournal of veterinary internal medicine2019
Assessment of the association between diabetes mellitus and chronic kidney disease in adult cats.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Mitochondria-associated endoplasmic reticulum membranes in canine and feline diabetic kidney disease: mechanistic links and nutritional implications.Frontiers in veterinary science · 2026Review
- Epidemiology of Chronic Kidney Disease (CKD) in Cats: An Analysis of the Factors Involved.Life (Basel, Switzerland) · 2025Article
- Glomerular ultrastructural change and vascular endothelial growth factor-A expression in diabetic cats.The Journal of small animal practice · 2025Article
- Effects of Beraprost with or without NOS Inhibition on Plasma Aldosterone and Hemodynamics in Healthy Cats.Veterinary sciences · 2024Article
- Beraprost and Overall Survival in Cats with Chronic Kidney Disease.Veterinary sciences · 2023Article
- 2021 AAFP Feline Senior Care Guidelines.Journal of feline medicine and surgery · 2021Article
- Assessment of the association between diabetes mellitus and chronic kidney disease in adult cats.Journal of veterinary internal medicine · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus is the main cause of chronic kidney disease (CKD) in humans. The relationship between the 2 diseases in cats is unclear.
objectiveTo assess the association between diabetes and CKD in a population of adult cats. ANIMALS: Five hundred sixty-one cats that attended 2 veterinary centers in Gran Canaria, Spain, between 2014 and 2016.
methodsMedical records were retrospectively reviewed. Cats aged 3 years or older, with sufficient data to define whether or not they had diabetes and CKD, were selected. Cats in critical condition, with dehydration or potential causes of prerenal azotemia and those treated with nephrotoxic drugs were excluded. Diagnosis of CKD was established when creatinine concentrations were >2 mg/dL, or serum creatinine 1.6-2 mg/dL and urine specific gravity <1.035, or serum creatinine 1.6-2 mg/dL and urine protein/creatinine ratio >0.4. Factors associated with CKD were identified through multivariate logistic regression analyses.
resultsSixty-seven (11.9%) cats had CKD and 16 (2.9%) cats had diabetes. Sixty cats without diabetes (11%) and 7 with diabetes (44%) had CKD. Among the latter, both conditions were diagnosed simultaneously in 6 cases, whereas diabetes preceded CKD in the other. Multivariate analysis showed that diabetes was significantly associated with CKD (odds ratio = 4.47; 95% confidence interval, 1.51-13.28; P = .007). Other variables associated with CKD were age and mixed breed. CONCLUSIONS AND CLINICAL IMPORTANCE: After adjusting for age, this study showed an association between diabetes and CKD in adult cats.
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