Evidence map›Paper›PMID 31304868›Full record

ArticleRNA biology2019

Single nucleotide polymorphism rs13079080 is associated with differential regulation of the succinate receptor 1 (SUCNR1) gene by miRNA-4470.

Elja M M Louer, Laura Lorés-Motta, Ana Mãdãlina Ion, Anneke I Den Hollander, Peter M T Deen

Open access · hybridAbstract read
In one paragraph

Article in RNA biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Elja M M LouerDept of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen , The Netherlands.
Laura Lorés-MottaDept of Ophthalmology, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center , Nijmegen , The Netherlands.
Ana Mãdãlina IonDept of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen , The Netherlands.
Anneke I Den HollanderDept of Ophthalmology, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center , Nijmegen , The Netherlands.
Peter M T DeenDept of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen , The Netherlands.
Radboud Institute for Molecular Life Sciences · NLRadboud University Medical Center · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress is a feature of many common diseases. It leads to excessive formation and subsequent release of the mitochondrial metabolite succinate, which acts as a signalling molecule through binding the succinate receptor (SUCNR1). Recently, a potential role for SUCNR1 was proposed in age-related macular degeneration (AMD), a common cause of vision loss in the elderly associated with increased oxidative stress. Here, we evaluated the potential effect of genetic variants in

Indexed as

Polymorphism, Single Nucleotide3' Untranslated RegionsAgedAged, 80 and overCase-Control StudiesFemaleGenetic Association StudiesGenotypeHumansMacular DegenerationMaleMicroRNAsOxidative StressReceptors, G-Protein-CoupledRetina3' Untranslated RegionsMicroRNAsReceptors, G-Protein-CoupledSUCNR1 protein, humanAMDgene expressionmicro-RNAoxidative stressretinaSUCNR1

Identifiers

PMID31304868
PMCPMC6779389
OpenAlexW2957204717

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.