Evidence map›Paper›PMID 31304402›Full record

ArticleNPJ digital medicine2019

Similar image search for histopathology: SMILY.

Narayan Hegde, Jason D Hipp, Yun Liu, Michael Emmert-Buck, Emily Reif, Daniel Smilkov, Michael Terry, Carrie J Cai, Mahul B Amin, Craig H Mermel and 4 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
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  7. Review
  8. Article
  9. Article
  10. Web engine for tumor pathology image retrievals on massive scales.bioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Content-Based Histopathological Image Retrieval.Sensors (Basel, Switzerland) · 2025
    Article
  13. On image search in histopathology.Journal of pathology informatics · 2024
    Review
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Narayan Hegde *Google AI Healthcare, Mountain View, CA 94043 USA.ORCID 0000-0002-8422-2908
Jason D Hipp *Google AI Healthcare, Mountain View, CA 94043 USA.
Yun LiuGoogle AI Healthcare, Mountain View, CA 94043 USA.
Michael Emmert-BuckAvoneaux Medical Institute, Baltimore, MD 21215 USA.
Emily ReifGoogle AI Healthcare, Mountain View, CA 94043 USA.
Daniel SmilkovGoogle AI Healthcare, Mountain View, CA 94043 USA.
Michael TerryGoogle AI Healthcare, Mountain View, CA 94043 USA.
Carrie J CaiGoogle AI Healthcare, Mountain View, CA 94043 USA.
Mahul B Amin3Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163 USA.
Craig H MermelGoogle AI Healthcare, Mountain View, CA 94043 USA.ORCID 0000-0002-0816-3395
Phil Q NelsonGoogle AI Healthcare, Mountain View, CA 94043 USA.
Lily H PengGoogle AI Healthcare, Mountain View, CA 94043 USA.
Greg S CorradoGoogle AI Healthcare, Mountain View, CA 94043 USA.
Martin C StumpeGoogle AI Healthcare, Mountain View, CA 94043 USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing availability of large institutional and public histopathology image datasets is enabling the searching of these datasets for diagnosis, research, and education. Although these datasets typically have associated metadata such as diagnosis or clinical notes, even carefully curated datasets rarely contain annotations of the location of regions of interest on each image. As pathology images are extremely large (up to 100,000 pixels in each dimension), further laborious visual search of each image may be needed to find the feature of interest. In this paper, we introduce a deep-learning-based reverse image search tool for histopathology images: Similar Medical Images Like Yours (SMILY). We assessed SMILY's ability to retrieve search results in two ways: using pathologist-provided annotations, and via prospective studies where pathologists evaluated the quality of SMILY search results. As a negative control in the second evaluation, pathologists were blinded to whether search results were retrieved by SMILY or randomly. In both types of assessments, SMILY was able to retrieve search results with similar histologic features, organ site, and prostate cancer Gleason grade compared with the original query. SMILY may be a useful general-purpose tool in the pathologist's arsenal, to improve the efficiency of searching large archives of histopathology images, without the need to develop and implement specific tools for each application.

Indexed as

Image processingMachine learningMedical imagingSoftware

Identifiers

PMID31304402
PMCPMC6588631

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.