Evidence map›Paper›PMID 31304331›Full record

ArticleNPJ digital medicine2018

A principled machine learning framework improves accuracy of stage II colorectal cancer prognosis.

Neofytos Dimitriou, Ognjen Arandjelović, David J Harrison, Peter D Caie

Abstract read
In one paragraph

Article in NPJ digital medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  7. Few-shot Tumor Bud Segmentation Using Generative Model in Colorectal Carcinoma.Proceedings of SPIE--the International Society for Optical Engineering · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Neofytos Dimitriou1School of Computer Science, University of St Andrews, St Andrews, KY16 9SX UK.
Ognjen Arandjelović1School of Computer Science, University of St Andrews, St Andrews, KY16 9SX UK.
David J Harrison2School of Medicine, University of St Andrews, St Andrews, KY16 9TF UK.
Peter D Caie2School of Medicine, University of St Andrews, St Andrews, KY16 9TF UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate prognosis is fundamental in planning an appropriate therapy for cancer patients. Consequent to the heterogeneity of the disease, intra- and inter-pathologist variability, and the inherent limitations of current pathological reporting systems, patient outcome varies considerably within similarly staged patient cohorts. This is particularly true when classifying stage II colorectal cancer patients using the current TNM guidelines. The aim of the present work is to address this problem through the use of machine learning. In particular, we introduce a data driven framework which makes use of a large number of diverse types of features, readily collected from immunofluorescence imagery. Its outstanding performance in predicting mortality in stage II patients (AUROC = 0:94), exceeds that of current clinical guidelines such as pT stage (AUROC = 0:65), and is demonstrated on a cohort of 173 colorectal cancer patients.

Indexed as

Cancer microenvironmentColorectal cancer

Identifiers

PMID31304331
PMCPMC6550189

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.