Evidence map›Paper›PMID 31304326›Full record

ReviewNPJ digital medicine2018

Agile research to complement agile development: a proposal for an mHealth research lifecycle.

Kumanan Wilson, Cameron Bell, Lindsay Wilson, Holly Witteman

Registry-linked trialAbstract readReview
In one paragraph

Review in NPJ digital medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05079984 (Agile Development of a Digital Exposure Treatment for Youth With Chronic Musculoskeletal Pain), which is not on this map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05079984 nacompletednot on this mapstarted 2022, after this paper: background citation

Agile Development of a Digital Exposure Treatment for Youth With Chronic Musculoskeletal Pain

TypeinterventionalSponsorStanford UniversityRan2022 to 2025Enrolled108ConditionsChronic Pain, Exposure, Adolescent Behavior, Child BehaviorArmsGraded exposure treatment (GET)
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. A Method for Enabling Digital Health Technologies in Clinical and Translational Research at an Academic Medical Center.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2025
    Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kumanan Wilson1Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Cameron Bell2Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Lindsay Wilson2Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Holly Witteman3Department of Family and Emergency Medicine, Université Laval, Quebec, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mobile health (mHealth) technology is increasingly being used, but academic evaluations supporting its use are not keeping pace. This is partly due to the disconnect between the traditional pharmaceutical approach to product evaluation, with its incremental approach, and the flexible way in which mHealth products are developed. An important step to addressing these problems lies in establishing agile research methods that complement the agile development methodologies used to create modern digital health applications. We describe an mHealth research model that mirrors traditional clinical research methods in its attention to safety and efficacy, while also accommodating the rapid and iterative development and evaluation required to produce effective, evidence-based, and sustainable digital products. This approach consists of a project identification stage followed by four phases of clinical evaluation: Phase 1: User Experience Design, Development, & Alpha Testing; Phase 2: Beta testing; Phase 3: Clinical Trial Evaluation; and Phase 4: Post-Market Surveillance. These phases include sample gating questions and are adapted to accommodate the unique nature of digital product development.

Indexed as

Medical researchPublic health

Identifiers

PMID31304326
PMCPMC6550198

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.