Evidence map›Paper›PMID 31304249›Full record

ReviewNPJ science of food2017

Food for thought: how nutrition impacts cognition and emotion.

Sarah J Spencer, Aniko Korosi, Sophie Layé, Barbara Shukitt-Hale, Ruth M Barrientos

Open access · goldAbstract readReview
In one paragraph

Review in NPJ science of food, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 6 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 6 syntheses or guidelines pooled it, 253 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. School food environment interventions for health and sustainability.The Cochrane database of systematic reviews · 2026
    Article
  18. Article
  19. Article
  20. Review

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 5 countries.

Sarah J Spencer1School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC 3788 Australia.
Aniko Korosi2Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, 1098 XH Netherlands.
Sophie Layé3Nutrition et Neurobiologie Intégrée, INRA, Bordeaux University, Bordeaux, UMR1286 France.
Barbara Shukitt-Hale4USDA-ARS, Human Nutrition Research Center On Aging at Tufts University, Boston, MA 02111-1524 USA.
Ruth M Barrientos5Department of Psychology & Neuroscience, and Center for Neuroscience, University of Colorado, Campus Box 345, Boulder, CO 80309-0345 USA.
NutriNeuro · FRRMIT University · AUTufts University · USUniversity of Amsterdam · NLUniversity of Colorado System · US

Funding

Neuroinflammation, Inflammatory Challenge, and MemoryR01AG028271 · NIA · UNIVERSITY OF COLORADO · PI MAIER, STEVEN F · 2006 to 2016
$3.8M
NIA NIH HHS R01 AG028271
6 · The paper itself

Abstract

More than one-third of American adults are obese and statistics are similar worldwide. Caloric intake and diet composition have large and lasting effects on cognition and emotion, especially during critical periods in development, but the neural mechanisms for these effects are not well understood. A clear understanding of the cognitive-emotional processes underpinning desires to over-consume foods can assist more effective prevention and treatments of obesity. This review addresses recent work linking dietary fat intake and omega-3 polyunsaturated fatty acid dietary imbalance with inflammation in developing, adult, and aged brains. Thus, early-life diet and exposure to stress can lead to cognitive dysfunction throughout life and there is potential for early nutritional interventions (e.g., with essential micronutrients) for preventing these deficits. Likewise, acute consumption of a high-fat diet primes the hippocampus to produce a potentiated neuroinflammatory response to a mild immune challenge, causing memory deficits. Low dietary intake of omega-3 polyunsaturated fatty acids can also contribute to depression through its effects on endocannabinoid and inflammatory pathways in specific brain regions leading to synaptic phagocytosis by microglia in the hippocampus, contributing to memory loss. However, encouragingly, consumption of fruits and vegetables high in polyphenolics can prevent and even reverse age-related cognitive deficits by lowering oxidative stress and inflammation. Understanding relationships between diet, cognition, and emotion is necessary to uncover mechanisms involved in and strategies to prevent or attenuate comorbid neurological conditions in obese individuals.

Indexed as

Neuroendocrine diseasesObesity

Identifiers

PMID31304249
PMCPMC6550267
OpenAlexW2768044583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.