Evidence map›Paper›PMID 31304224›Full record

ArticleInternational journal of pediatrics & adolescent medicine2019

Screening of Egyptian obese children and adolescents for insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme gene.

Zeinab A El-Kabbany, Rasha T Hamza, Dina M Shinkar, Tarek M Kamal, Reham I Abdelmageed, Mina S Said, Mennatullah I Abdel-Hamid

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pediatrics & adolescent medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zeinab A El-KabbanyPediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Rasha T HamzaPediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Dina M ShinkarPediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Tarek M KamalHuman Medical Genetics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Reham I AbdelmageedPediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mina S SaidEgyptian Ministry of Health, Cairo, Egypt.
Mennatullah I Abdel-HamidEgyptian Ministry of Health, Cairo, Egypt.
Ain Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background/aims: The role of angiotensin-converting enzyme (ACE) gene polymorphism in the development of obesity and hypertension in children has not been widely studied. We aimed to screen Egyptian obese children and adolescents for insertion/deletion (I/D) polymorphism in the ACE gene.

methodsOne hundred forty-two children and adolescents were included (70 with simple obesity and 72 controls). Blood pressure was measured, and anthropometric parameters were assessed in all included children and adolescents. Fasting lipid profile, fasting glucose, and insulin were measured. DNA extraction and ACE I/D polymorphism genotyping were also performed.

resultsObese children had a higher frequency of DD genotype (30% in obese versus 11.1% in controls,

conclusionDD genotype and D-allele of the ACE gene polymorphism were associated with obesity and with hypertension and pre-hypertension in Egyptian children.

Indexed as

ACEACE, The angiotensin-converting enzymeBMI, Body mass indexHDL, High density lipoproteinsHOMA-IR, homeostasis model assessment for insulin resistance indexHypertensionLDL, low density lipoproteinsObesityPolymorphism

Identifiers

PMID31304224
PMCPMC6603068
OpenAlexW2916389582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.