ArticleOpen forum infectious diseases2019
Dengue Underestimation in Guangzhou, China: Evidence of Seroprevalence in Communities With No Reported Cases Before a Large Outbreak in 2014.
Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Characterizing dengue transmission in rural areas: A systematic review.PLoS neglected tropical diseases · 2023Pooled it
- Socioeconomic risk markers of arthropod-borne virus (arbovirus) infections: a systematic literature review and meta-analysis.BMJ global health · 2022Pooled it
- The worldwide seroprevalence of DENV, CHIKV and ZIKV infection: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2021Pooled it
- Antibody landscapes of arboviral exposure across China revealed by high-throughput seroprofiling from a peptide epitope library.Infectious diseases of poverty · 2026Article
- Consultation behaviors and factors influencing hesitation to seek medical care among local dengue patients in Guangzhou, China: a retrospective analysis.BMC public health · 2025Article
- "Dengue fever is not just urban or rural: Reframing its spatial categorization."Social science & medicine (1982) · 2024Article
- Estimating Dengue Transmission Intensity in China Using Catalytic Models Based on Serological Data.Tropical medicine and infectious disease · 2023Article
- Epidemiology of Indigenous Dengue Cases in Zhejiang Province, Southeast China.Frontiers in public health · 2022Article
- The Seroprevalence of Dengue Virus Infection and Its Association With Iron (Fe) Level in Pregnant Women in Guangzhou, China.Frontiers in medicine · 2021Article
- Epidemiological characteristics of dengue in mainland China from 1990 to 2019: A descriptive analysis.Medicine · 2020Article
- Determination of Factors Affecting Dengue Occurrence in Representative Areas of China: A Principal Component Regression Analysis.Frontiers in public health · 2020Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDengue has become a serious public health problem in southern China particularly with a record-breaking outbreak in 2014. Serological evidence from areas with no known dengue cases reported prior to 2014 could provide information on possible unrecognized circulation of dengue virus (DENV) before this outbreak.
methodBetween March and May 2015, we performed a cross-sectional serosurvey using a stratified random sampling method among individuals aged 1-84 years-old in 7 communities in Guangzhou with no reported dengue cases before 2014. Sera of subjects were initially screened with the indirect DENV IgG enzyme-linked immunosorbent assay, and positive samples were further tested by the indirect immunofluorescence assay to identify specific serotypes.
resultsA total of 850 subjects had complete information available. The overall seroprevalence against DENV was 6.59% (56 of 850; 95% CI, 4.92%-8.26%). The seroprevalence increased with age in general (3.86%, 4.58%, 8.72%, 7.22%, and 10.69% among participants in ≤14, 15-29, 30-44, 45-59 and ≥60 years age group, respectively). Living in rural or peri-urban communities and longer years of residence therein were risk factors for higher seroprevalence, whereas wearing long sleeves and pants when outdoors was associated with lower seroprevalence. Of the total subjects, 55.36% (31 of 56) sera were successfully identified with specific serotypes, with 12.90% (4 of 31) being coinfected with 2 serotypes.
conclusionsDengue transmission in the study communities had occurred prior to the 2014 massive outbreak, possibly for many years, but went undiagnosed and unreported. A proportion of the study population experienced secondary infection as different serotypes of DENV increased the risk for severe diseases. Active surveillance and education of both healthcare providers and the general population should be conducted in areas at risk for dengue emergence in order to better reduce disease burden.
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