Evidence map›Paper›PMID 31304185›Full record

ArticleOpen forum infectious diseases2019

Efficient HIV-1

Giovanna Rappocciolo, Nicolas Sluis-Cremer, Charles R Rinaldo

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Antigen Presenting Cell-Mediated HIV-1Medical research archives · 2023
    Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Giovanna RappoccioloDepartment of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0002-6415-0847
Nicolas Sluis-CremerDepartment of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Charles R RinaldoDepartment of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
University of Pittsburgh · US

Funding

University of Pittsburgh Multicenter AIDS Cohort Study (MACS)U01AI035041 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARTINSON, JEREMY JAMES, RINALDO, CHARLES R · 1993 to 2018
$71.4M
NNRTI induced conformational changes in HIV-1 RT - Equipment SupplementR01GM068406 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SLUIS-CREMER, NICOLAS PAUL · 2003 to 2017
$3.7M
Novel mechanisms of HIV resistance to RTIsR01AI081571 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SLUIS-CREMER, NICOLAS PAUL · 2009 to 2018
$3.0M
Cholesterol-dependent control of HIV progression by antigen presenting cellsR01AI118403 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAPPOCCIOLO, GIOVANNA, RINALDO, CHARLES R · 2015 to 2019
$2.6M
NIAID NIH HHS R01 AI081571NIAID NIH HHS R01 AI118403NIAID NIH HHS U01 AI035041NIGMS NIH HHS R01 GM068406
6 · The paper itself

Abstract

backgroundAntiretroviral therapy (ART) has dramatically improved the quality of life of people with HIV-1 infection (PWH). However, it is not curative, and interruption of ART results in rapid viral rebound. Cell-to-cell transfer of HIV-1, or

methodsAPC from HIV seronegative donors treated with ART

resultsHere we show in vitro that antiretroviral drugs did not block the ability of DCs and B cells to

conclusionsOur study supports a role for HIV-1

Indexed as

antigen-presenting cellsARTB lymphocytesdendritic cellsHIVtrans infection

Identifiers

PMID31304185
PMCPMC6613953
OpenAlexW2945367232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.