ArticleFungal biology and biotechnology2019
The fungal gene cluster for biosynthesis of the antibacterial agent viriditoxin.
Article in Fungal biology and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
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- Genome sequencing and molecular networking analysis of the wild fungus Anthostomella pinea reveal its ability to produce a diverse range of secondary metabolites.Fungal biology and biotechnology · 2024Article
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- A Polyphasic Approach including Whole Genome Sequencing RevealsJournal of fungi (Basel, Switzerland) · 2023Article
- Subcellular localization of fungal specialized metabolites.Fungal biology and biotechnology · 2022Review
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- Preservation stress resistance of melanin deficient conidia from Paecilomyces variotii and Penicillium roqueforti mutants generated via CRISPR/Cas9 genome editing.Fungal biology and biotechnology · 2021Article
- Interspecies Genomic Variation and Transcriptional Activeness of Secondary Metabolism-Related Genes inFrontiers in fungal biology · 2021Article
- Genomic clustering within functionally related gene families inComputational and structural biotechnology journal · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundViriditoxin is one of the 'classical' secondary metabolites produced by fungi and that has antibacterial and other activities; however, the mechanism of its biosynthesis has remained unknown.
resultsHere, a gene cluster (
conclusionsThe predicted pathway for the synthesis of viriditoxin was established by a combination of genomics, bioinformatics, gene disruption and chemical analysis processes. Hence, this work reveals the basis for the synthesis of an understudied class of fungal secondary metabolites and provides a new model species for understanding the synthesis of biaryl compounds with a chiral axis.
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