Evidence map›Paper›PMID 31303986›Full record

ArticleMedChemComm2019

Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues.

Takashi Misawa, Chihiro Goto, Norihito Shibata, Motoharu Hirano, Yutaka Kikuchi, Mikihiko Naito, Yosuke Demizu

Abstract read
In one paragraph

Article in MedChemComm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Takashi MisawaDivision of Organic Chemistry , National Institute of Health Sciences , 3-25-26, Tonomachi , Kawasaki , Kanagawa 210-9501 , Japan . Email: demizu@nihs.go.jp.ORCID 0000-0002-0339-8750
Chihiro GotoDivision of Organic Chemistry , National Institute of Health Sciences , 3-25-26, Tonomachi , Kawasaki , Kanagawa 210-9501 , Japan . Email: demizu@nihs.go.jp.
Norihito ShibataDivision of Molecular Target and Gene Therapy Products , National Institute of Health Sciences , 3-25-26, Tonomachi , Kawasaki , Kanagawa 210-9501 , Japan.
Motoharu HiranoDivision of Organic Chemistry , National Institute of Health Sciences , 3-25-26, Tonomachi , Kawasaki , Kanagawa 210-9501 , Japan . Email: demizu@nihs.go.jp.
Yutaka KikuchiDivision of Microbiology , National Institute of Health Sciences , 3-25-26, Tonomachi , Kawasaki , Kanagawa 210-9501 , Japan.
Mikihiko NaitoDivision of Molecular Target and Gene Therapy Products , National Institute of Health Sciences , 3-25-26, Tonomachi , Kawasaki , Kanagawa 210-9501 , Japan.
Yosuke DemizuDivision of Organic Chemistry , National Institute of Health Sciences , 3-25-26, Tonomachi , Kawasaki , Kanagawa 210-9501 , Japan . Email: demizu@nihs.go.jp.ORCID 0000-0001-7521-4861

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) have garnered much attention as novel therapeutic agents against infectious diseases. They exhibit antimicrobial activity through microbial membrane disruption based on their amphipathic properties. In this study, we rationally designed and synthesized a series of novel AMPs

Identifiers

PMID31303986
PMCPMC6590335

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.