Evidence map›Paper›PMID 31303978›Full record

ReviewComputational and structural biotechnology journal2019

FOXO3 on the Road to Longevity: Lessons From SNPs and Chromatin Hubs.

Paola Sanese, Giovanna Forte, Vittoria Disciglio, Valentina Grossi, Cristiano Simone

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Computational and structural biotechnology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Interaction BetweenNutrients · 2025
    Observational
  7. Article
  8. Article
  9. Clinical and neuropathological analysis of Down syndrome over 7 decades of life.Journal of neuropathology and experimental neurology · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Personalized Financial Planning Using Applied Genetics.Cold Spring Harbor perspectives in medicine · 2023
    Review
  15. Article
  16. Article
  17. miR-122-5p Regulates Renal Fibrosis In Vivo.International journal of molecular sciences · 2022
    Article
  18. Article
  19. The Association Between Longevity-Associated FOXO3 Allele and Heart Disease in Septuagenarians and Octogenarians: The SONIC Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Paola SaneseMedical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari Aldo Moro, Piazza G. Cesare, 11, 70124 Bari, Italy.
Giovanna ForteMedical Genetics, National Institute of Gastroenterology 'S. de Bellis' Research Hospital, Via Turi, 27, 70013 Castellana Grotte (BA), Italy.
Vittoria DisciglioMedical Genetics, National Institute of Gastroenterology 'S. de Bellis' Research Hospital, Via Turi, 27, 70013 Castellana Grotte (BA), Italy.
Valentina GrossiMedical Genetics, National Institute of Gastroenterology 'S. de Bellis' Research Hospital, Via Turi, 27, 70013 Castellana Grotte (BA), Italy.
Cristiano SimoneMedical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari Aldo Moro, Piazza G. Cesare, 11, 70124 Bari, Italy.
Gastroenterology Hospital "Saverio de Bellis" · ITUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Health span is driven by a precise interplay between genes and the environment. Cell response to environmental cues is mediated by signaling cascades and genetic variants that affect gene expression by regulating chromatin plasticity. Indeed, they can promote the interaction of promoters with regulatory elements by forming active chromatin hubs.

Indexed as

3C, Chromosome conformation capture5′UTR, Five prime untranslated regionACH, Active chromatin hubAgingChromatin hubERE, Estrogen-responsive elementER, Estrogen receptorFHRE, Forkhead response elementFOXO3FOXO3, Forkhead box 3GPx, Glutathione peroxidaseGWAS, Genome-wide association studyHPS, Hamartomatous polyposis syndromeHSE, Heat shock elementHSF1, Heat shock factor 1IGF-1, Insulin growth factor-1LD, Linkage disequilibriumLongevityPHTS, PTEN hamartoma tumor syndromePJS, Peutz-Jeghers syndromeROS, Reactive oxygen speciesSNPSNP, Single nucleotide polymorphismSNV, Single nucleotide variantSOD2, Superoxide dismutase 2TAD, Topologically associated domain

Identifiers

PMID31303978
PMCPMC6606898
OpenAlexW2951558399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.