Evidence map›Paper›PMID 31303919›Full record

ArticleThe Pan African medical journal2019

Evaluation of interleukin 8 and interleukin 10 cytokines in liquid based cervical cytology samples.

Daniel David Osiagwu, Alfred Ederialo Azenabor, Abimbola Akinduro Osijirin, Philomina Ikuoyah Awopetu, Folasade Ruth Oyegbami

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Pan African medical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Daniel David OsiagwuDepartment of Medical Laboratory Science, University of Lagos, Nigeria.
Alfred Ederialo AzenaborDepartment of Medical Laboratory Science, University of Lagos, Nigeria.
Abimbola Akinduro OsijirinLagos University Teaching Hospital, Lagos, Nigeria.
Philomina Ikuoyah AwopetuDepartment of Medical Laboratory Science, University of Lagos, Nigeria.
Folasade Ruth OyegbamiDepartment of Medical Laboratory Science, University of Lagos, Nigeria.
University of Lagos · NGLagos University Teaching Hospital · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductioninflammatory cytokines have been associated with various cancers, including cervical cancers. Interpreting cytokine expression in liquid based cervical samples is quite challenging. This study is aimed at evaluating the levels of interleukin 8 and 10 in liquid based cervical samples.

methodsthis is a descriptive analytical study carried out on eighty five (85) subjects aged between 23 and 68 years. Cervical samples were collected in liquid based medium and smears later examined after staining with Papanicolaou technique. These were categorized into low grade intra-epithelial lesion/malignancy, high grade intraepithelial lesion/malignancy according to the degree of dyskaryosis. Concentrations of interleukin 8 and interleukin 10 in the samples were determined by enzyme linked immunosorbent assay.

resultsthe mean age, standard deviation (SD) of the study subjects were 40.6 (7.8) years. A total number of 79 females (92.9%) were negative for intra-epithelial lesion/malignancy (NILM), while 4 (4.71%) and 2 (2.35%) were positive for low grade intra-epithelial lesion/malignancy (LILM) and high grade intra-epithelial lesion (HILM) respectively. While mean levels of interleukin 8 increased with the degree of malignancy, (107.27 ± 11.88pg/ml) in LILM, (114.80 ± 2.12pg/ml) in HILM when compared with NILM (88.39 ± 18.06pg/ml), (f = 0.700, p = 0.018); the mean levels of interleukin 10 was comparable between these groups (p ≥ 0.05). Pearson correlation coefficient analysis showed a negative association between interleukin 8 and interleukin 10 (r = -1.999, p = 0.000) in LILM.

conclusioninterleukin 8 cytokines in cervical cancer is associated with the degree of malignancy. Possible anti-inflammatory effect of interleukin 10 was not observed.

Indexed as

AdultAgedCervix UteriEnzyme-Linked Immunosorbent AssayFemaleHumansInterleukin-10Interleukin-8Middle AgedPapanicolaou TestUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsYoung AdultCXCL8 protein, humanIL10 protein, humanInterleukin-10Interleukin-8cervical cancerCytokinesinflammation

Identifiers

PMID31303919
PMCPMC6607241
OpenAlexW2923885000

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.