ArticleDiabetology & metabolic syndrome2019
The dietary acid load is higher in subjects with prediabetes who are at greater risk of diabetes: a case-control study.
Article in Diabetology & metabolic syndrome, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Prevalence of prediabetes and associated risk factors in the Eastern Mediterranean Region: a systematic review.BMC public health · 2025Pooled it
- Association of High Dietary Acid Load With the Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies.Frontiers in nutrition · 2022Pooled it
- Association of Dietary Acid Load with Metabolic Syndrome-Related Parameters Following Eating Habit Modification in Korean Adults.Nutrients · 2026Article
- Association Between Dietary Cholesterol Intake and Prediabetes: A Population-Based Study.International journal of endocrinology · 2026Article
- Association of dietary acid load with diabetes and glucose metabolism index in Chinese adults: a cross-sectional study.Food & nutrition research · 2026Article
- The association of diet-dependent acid load with gastrointestinal cancer risk in the Cancer Screenee Cohort in Korea.European journal of clinical nutrition · 2025Article
- The relationship between dietary phytochemical index and risk of gestational diabetes mellitus in Iran: a case-control study.BMC nutrition · 2025Article
- Association between dietary acid load and risk of metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes.Frontiers in nutrition · 2025Article
- Correlation between dietary acid-base load and chronic kidney disease patients with type 2 diabetes mellitus.Frontiers in nutrition · 2025Article
- Dietary acid load and the risk of events of mortality and kidney replacement therapy in people with chronic kidney disease: the Progredir Cohort Study.European journal of clinical nutrition · 2024Article
- Dietary acid load, alternative healthy eating index score, and bacterial vaginosis: is there any association? A case-control study.BMC infectious diseases · 2022Article
- Dietary acid load modifies the effects of ApoA2-265 T > C polymorphism on lipid profile and serum leptin and ghrelin levels among type 2 diabetic patients.BMC endocrine disorders · 2022Article
- Quantifying dietary acid load in U.S. cancer survivors: an exploratory study using NHANES data.BMC nutrition · 2022Article
- Dietary Acid Load Is Positively Associated With Risk of Gestational Diabetes Mellitus in a Prospective Cohort of Chinese Pregnant Women.Frontiers in nutrition · 2022Article
- No Interaction Effect between Interleukin-6 Polymorphisms and Acid Ash Diet with Bone Resorption Marker in Postmenopausal Women.International journal of environmental research and public health · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to examine the association of dietary acid load and prediabetes in a case-control study.
methodsThis study recruited 297 subjects including 147 prediabetic subjects and 150 controls referred to diabetes screening center in Shahreza, Iran. Participants were frequency-matched by sex and age. Blood pressure, anthropometric measures and blood glucose levels were measured. Dietary intake was assessed using a validated 168-items food frequency questionnaire (FFQ). The dietary acid load scores including the potential renal acid load (PRAL) and net endogenous acid production (NEAP) were calculated based on nutrients intake. NEAP and PRAL scores were categorized by quartiles based on the distribution of controls. Logistic regression models were used to estimate multivariable odds ratio (OR) of prediabetes across the energy-adjusted and sex-specific quartiles of NEAP and PRAL scores.
resultsParticipants of control group in the higher quartiles of NEAP and PRAL tended to have higher body weight compared to the lower quartiles (P-trend < 0.04). After adjustment for multiple confounding variables, participants in the highest quartiles of NEAP and PRAL had increased OR for prediabetes (OR = 14.48 95% CI 5.64-37.19), and (OR = 25.61 95% CI 9.63-68.08) (P-trend < 0.001), respectively.
conclusionOur data indicated subjects with prediabetes had diets with more acid-forming potential than control group. Our findings suggest that higher dietary acid load was associated with increased prediabetes morbidity. Interventional studies are warranted to elucidate the role of acidogenic diets in the development of prediabetes.
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