Evidence map›Paper›PMID 31303755›Full record

ReviewNeuropsychiatric disease and treatment2019

The role of long noncoding RNA in traumatic brain injury.

Zhenxing Li, Kaiwei Han, Danfeng Zhang, Jigang Chen, Zheng Xu, Lijun Hou

Open access · goldAbstract readReview
In one paragraph

Review in Neuropsychiatric disease and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Effect of exosomeZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. The Emerging Role of lncRNAs in Spinal Cord Injury.BioMed research international · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zhenxing Li *Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Kaiwei Han *Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Danfeng Zhang *Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Jigang ChenDepartment of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Zheng XuDepartment of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Lijun HouDepartment of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Second Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI), a mainly lethal and highly debilitating condition, is increasing worldwide. However, the underlying mechanism has not been fully elucidated and effective therapy is needed. Long noncoding RNAs (lncRNAs), which form a major class of noncoding RNAs, have emerged as novel targets for regulating physiological functions and mediating numerous neurological diseases. Notably, gene expression profile analyses have demonstrated aberrant changes in lncRNA expression in the cerebral cortex and hippocampus of rats, mice and human after TBI. lncRNAs may be associated with multiple pathophysiological processes following TBI and might play a crucial role in complications of TBI, such as traumatic optic neuropathy due to the regulation of specific signaling pathways. Some lncRNAs have also been found to be therapeutic targets for motor and cognitive recovery after TBI. lncRNAs may be promising biomarkers for TBI diagnosis, treatment, and prognosis prediction. However, further research isneeded to clarify the underlying mechanisms and therapeutic effects of lncRNAs on TBI. We review the current progress of studies on lncRNAs in TBI to draw more attention to their roles in this debilitating condition.

Indexed as

long non-coding RNAneuropathytraumatic brain injury

Identifiers

PMID31303755
PMCPMC6605043
OpenAlexW2953861663

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.