Evidence map›Paper›PMID 31303682›Full record

ArticleSimulation2018

JigCell Model Connector: building large molecular network models from components.

Thomas C Jones, Stefan Hoops, Layne T Watson, Alida Palmisano, John J Tyson, Clifford A Shaffer

Abstract read
In one paragraph

Article in Simulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A case for the reuse and adaptation of mechanistic computational models to study transplant immunology.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thomas C JonesDepartment of Computer Science, Virginia Tech, Blacksburg, VA, USA.ORCID 0000-0001-9264-1507
Stefan HoopsBiocomplexity Institute, Virginia Tech, Blacksburg, VA, USA.
Layne T WatsonDepartment of Computer Science, Virginia Tech, Blacksburg, VA, USA.
Alida PalmisanoDepartment of Computer Science, Virginia Tech, Blacksburg, VA, USA.
John J TysonDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, USA.
Clifford A ShafferDepartment of Computer Science, Virginia Tech, Blacksburg, VA, USA.ORCID 0000-0003-0001-0295

Funding

COPASI software for modeling and simulation of biochemical networksR01GM080219 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI HOOPS, STEFAN, MENDES, PEDRO · 2007 to 2019
$5.4M
Stochastic Models of Cell Cycle Regulation in EukaryotesR01GM078989 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI PECCOUD, JEAN M, TYSON, JOHN J. · 2006 to 2018
$5.3M
NIGMS NIH HHS R01 GM078989NIGMS NIH HHS R01 GM080219
6 · The paper itself

Abstract

The growing size and complexity of molecular network models makes them increasingly difficult to construct and understand. Modifying a model that consists of tens of reactions is no easy task. Attempting the same on a model containing hundreds of reactions can seem nearly impossible. We present the JigCell Model Connector, a software tool that supports large-scale molecular network modeling. Our approach to developing large models is to combine smaller models, making the result easier to comprehend. At the base, the smaller models (called modules) are defined by small collections of reactions. Modules connect together to form larger modules through clearly defined interfaces, called ports. In this work, we enhance the port concept by defining three types of ports. An output port is linked to an internal component that will send a value. An input port is linked to an internal component that will receive a value. An equivalence port is linked to an internal component that will both receive and send values. Not all modules connect together in the same way; therefore, multiple connection options need to exist.

Indexed as

computational systems biologyhierarchical model compositionJigCellmodeling toolSBMLsoftware

Identifiers

PMID31303682
PMCPMC6626305

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.