Evidence map›Paper›PMID 31303424›Full record

ArticleCell metabolism2019

Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling.

Junfeng Bi, Taka-Aki Ichu, Ciro Zanca, Huijun Yang, Wei Zhang, Yuchao Gu, Sudhir Chowdhry, Alex Reed, Shiro Ikegami, Kristen M Turner and 12 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 1 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 1 synthesis or guideline pooled it, 227 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Dyslipidaemias in cancer patients.European heart journal · 2026
    Review
  4. Article
  5. Article
  6. Advances in Lipid Metabolism Reprogramming in Hepatocellular Carcinoma.Journal of clinical and translational hepatology · 2026
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
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  19. Review
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73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 2 countries.

Junfeng BiLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA.
Taka-Aki IchuDepartment of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Ciro ZancaLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA.
Huijun YangLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA.
Wei ZhangDepartment of Medicine, UCSD School of Medicine, La Jolla, CA 92093, USA.
Yuchao GuLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Molecular and Medical Pharmacology David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.
Sudhir ChowdhryLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA.
Alex ReedDepartment of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Shiro IkegamiDepartment of Neurological Surgery, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Kristen M TurnerLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA.
Wenjing ZhangLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA.
Genaro R VillaLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Molecular and Medical Pharmacology David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.
Sihan WuLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA.
Oswald QuehenbergerDepartment of Medicine, UCSD School of Medicine, La Jolla, CA 92093, USA; Department of Pharmacology, UCSD School of Medicine, La Jolla, CA 92093, USA.
William H YongDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Harley I KornblumDepartment of Molecular and Medical Pharmacology David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen UCLA School of Medicine, Los Angeles, CA, USA.
Jeremy N RichDivision of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Timothy F CloughesyDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Webster K CaveneeLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Medicine, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA.
Frank B FurnariLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA.
Benjamin F CravattDepartment of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Paul S MischelLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address: pmischel@ucsd.edu.
University of California, San Diego · USLudwig Cancer Research · USUniversity of California, Los Angeles · USScripps Research Institute · USChiba University · JPMoores Cancer CenterUCLA Jonsson Comprehensive Cancer Center

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David A. Nathanson · 2017 to 2026
$25.2M
Chemical Proteomic Platforms for Radically Expanding Cancer DruggabilityR35CA231991 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI BENJAMIN F CRAVATT · 2018 to 2026
$9.5M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
The role of mTORC2 in reprogramming cancer cell metabolismR01NS073831 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MISCHEL, PAUL S · 2011 to 2020
$3.4M
NCI NIH HHS P50 CA211015NCI NIH HHS R35 CA231991NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS073831
6 · The paper itself

Abstract

Advances in DNA sequencing technologies have reshaped our understanding of the molecular basis of cancer, providing a precise genomic view of tumors. Complementary biochemical and biophysical perspectives of cancer point toward profound shifts in nutrient uptake and utilization that propel tumor growth and major changes in the structure of the plasma membrane of tumor cells. The molecular mechanisms that bridge these fundamental aspects of tumor biology remain poorly understood. Here, we show that the lysophosphatidylcholine acyltransferase LPCAT1 functionally links specific genetic alterations in cancer with aberrant metabolism and plasma membrane remodeling to drive tumor growth. Growth factor receptor-driven cancers are found to depend on LPCAT1 to shape plasma membrane composition through enhanced saturated phosphatidylcholine content that is, in turn, required for the transduction of oncogenic signals. These results point to a genotype-informed strategy that prioritizes lipid remodeling pathways as therapeutic targets for diverse cancers.

Indexed as

Gene Amplification1-Acylglycerophosphocholine O-AcyltransferaseA549 CellsAnimalsCell SurvivalErbB ReceptorsFemaleGene Expression Regulation, NeoplasticGenotypeHeterograftsHumansMiceMice, NudeNeoplasmsOncogenesPC-3 Cells1-Acylglycerophosphocholine O-AcyltransferaseEGFR protein, humanepidermal growth factor receptor VIIIErbB ReceptorsLpcat1 protein, humanPhospholipidscancer dependencycancer metabolismgene amplificationgrowth factor signalingmembrane lipid remodeling

Identifiers

PMID31303424
PMCPMC6742496
OpenAlexW2956607536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.