ArticleClinical therapeutics2019
The Impact of the Opioid Epidemic on Children and Adolescents.
Article in Clinical therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Impact of exposure to opioids in pregnancy on offspring developmental outcomes in the preschool years: an umbrella review.BMJ paediatrics open · 2025Pooled it
- Intravenous acetaminophen for postoperative pain control after open abdominal and thoracic surgery in pediatric patients: a systematic review and meta-analysis.Pediatric surgery international · 2022Pooled it
- Racial/Ethnic and Regional Disparities in Opioid-Involved Overdose Deaths among Children and Adolescents in the United States.Journal of racial and ethnic health disparities · 2026Article
- Parental death and parental substance use problems during childhood and the risk of DSM-5 substance use, suicidality and mental health disorders.Social psychiatry and psychiatric epidemiology · 2026Article
- Feasibility and acceptability of a novel substance use prevention intervention.Pilot and feasibility studies · 2026Article
- Addressing Workforce Challenges with an Apprenticeship-Based Training Program for Paraprofessionals in Behavioral Health: Conceptual Framework and Effectiveness.Behavioral sciences (Basel, Switzerland) · 2026Article
- Intraoperative Low-Dose Methadone for Pediatric Posterior Spinal Fusion: A Single-Center Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Perspectives on addiction-related problems in Vietnam.Addiction (Abingdon, England) · 2026Review
- Family Dynamics and Opioid Misuse Among Black Americans: The Mediating Role of Emotional Support.Couple & family psychology · 2025Article
- Compliance and Satisfaction With a Protocol for Identifying Novel Targets to Support Postpartum Opioid Use Disorder Recovery: Prospective Cohort Study.JMIR formative research · 2025Article
- Neurodevelopmental challenges at age four following fetal exposure to maternal opioid maintenance treatment.Pediatric research · 2025Article
- Parental Diseases of Despair and Suicidal Events in Their Children.JAMA network open · 2025Article
- Trends in Prenatal Polysubstance Exposure.Families in society : the journal of contemporary human services · 2025Article
- Orphanhood and caregiver death among children in the United States by all-cause mortality, 2000-2021.Nature medicine · 2025Article
- Nurses' Experiences and Perspectives Caring for People With Substance Use Disorder and Their Families: A Qualitative Descriptive Study.International journal of mental health nursing · 2025Article
- Opioid versus Non-Opioid Postoperative Pain Management for Pediatric Supracondylar Humerus Fractures.The Iowa orthopaedic journal · 2025Article
- Prolonged magnesium sulfate infusion as adjuvant analgesia in postoperative transplant patients in the pediatric ICU: Preliminary results of a feasibility study.Paediatric & neonatal pain · 2024Article
- Opioid use, prescribing patterns, and disposal after surgical procedures.Exploratory research in clinical and social pharmacy · 2024Article
- A Qualitative Study of Health Equity's Role in Community Coalition Development.Health education & behavior : the official publication of the Society for Public Health Education · 2024Article
- Estimated Number of Children Who Lost a Parent to Drug Overdose in the US From 2011 to 2021.JAMA psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although an epidemic of opioid-related overdose deaths has continued to increase in the United States for 2 decades, the impact of opioid use disorders (OUDs) on children and families receives minimal attention. The purpose of this commentary was to provide an overview of the impact of the opioid epidemic on children and adolescents, as well as to summarize challenges to improving outcomes for children. Children and adolescents who grow up in households with opioid misuse and OUDs may experience a myriad of adverse consequences, including: increased risk of mental health problems and drug use; accidental opioid poisoning; increased risk of developing a substance use disorder; and family dissolution that results from parents' incarceration, foster care placement, or loss of parent to an opioid overdose. Parental drug use may result in child neglect or deficits in parent-child attachment, and parents with an OUD may be less likely to be reunified with their children. OUD treatment is effective at reducing parental opioid use and improving child outcomes; however, stigma and cross-system collaboration may limit access to treatment and timely reunification of families. Children are the most vulnerable witnesses of the opioid epidemic, and further research is urgently needed to expand prevention interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.