Trial reportBiological psychiatry2019
Strengthened Hippocampal Circuits Underlie Enhanced Retrieval of Extinguished Fear Memories Following Mindfulness Training.
Trial report in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 64 citations in OpenAlex.
- Effect of app-based mindfulness on extinction recall - a 7T-fMRI study.Scientific reports · 2026Trial
- Hippocampal circuits underlie improvements in self-reported anxiety following mindfulness training.Brain and behavior · 2020Trial
- Neural correlates of meditation-induced changes in self-related traits: a resting state fMRI study.Mindfulness · 2026Article
- Effectiveness of digital and mobile-based interventions on sleep quality among nurses: a systematic review and meta-analysis.Frontiers in digital health · 2026Review
- A systematic review of spontaneous recovery in human fear conditioning.Frontiers in behavioral neuroscience · 2026Review
- Unlocking deep relaxation: the power of rhythmic breathing on brain rhythms.Npj mental health research · 2025Article
- Neural correlates of reduction in self-judgment after mindful self-compassion training: A pilot study with resting state fMRI.Journal of mood and anxiety disorders · 2025Article
- Breath-Counting Task Enhances the Sensitivity of Fear Acquisition.Behavioral sciences (Basel, Switzerland) · 2025Article
- Effects of a mindfulness intervention on emotion differentiation and heart rate variability.Frontiers in human neuroscience · 2025Review
- A Mindfulness-Based Lifestyle Intervention for Dementia Risk Reduction: Protocol for the My Healthy Brain Feasibility Randomized Controlled Trial.JMIR research protocols · 2024Article
- Temporal dynamics and long-term effects of a mindfulness-based intervention for young adults with adverse childhood experiences.Mindfulness · 2024Article
- Beneficial effects of mindfulness-based intervention on hippocampal volumes and episodic memory for childhood adversity survivors.Journal of affective disorders reports · 2024Article
- Distributed neural representations of conditioned threat in the human brain.Nature communications · 2024Article
- Smaller Hippocampal Volume Is Associated With Reduced Posttraumatic Stress Symptoms in Children With Cancer and Survivors Following a Brief Novel Martial Arts-Based Intervention.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Childhood adversity severity modulates the associations between adaptive psychological changes and amygdala volumetric changes in response to behavioral interventions.Journal of affective disorders reports · 2024Article
- Effects of web-based mindfulness training on psychological outcomes, attention, and neuroplasticity.Scientific reports · 2023Article
- Within-Person Modulation of Neural Networks following Interoceptive Awareness Training through Mindful Awareness in Body-Oriented Therapy (MABT): A Pilot Study.Brain sciences · 2023Article
- The Missing Ingredient: How Misogyny and the Patriarchy Sabotage our Clinical Practice and Research.Clinical neuropsychiatry · 2023Article
- Interoception in Fear Learning and Posttraumatic Stress Disorder.Focus (American Psychiatric Publishing) · 2023Article
- Detection of neuronal defensive discharge information transmission and characteristics in periaqueductal gray double-subregions using PtNP/PEDOT:PSS modified microelectrode arrays.Microsystems & nanoengineering · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe role of hippocampus in context-dependent recall of extinction is well recognized. However, little is known about how intervention-induced changes in hippocampal networks relate to improvements in extinction learning. In this study, we hypothesized that mindfulness training creates an optimal exposure condition by heightening attention and awareness of present moment sensory experience, leading to enhanced extinction learning, improved emotion regulation, and reduced anxiety symptoms.
methodsWe tested this hypothesis in a randomized controlled longitudinal study design using a 2-day fear conditioning and extinction protocol. The mindfulness training group included 42 participants (28 women) and the control group included 25 participants (15 women).
resultsWe show that mindfulness training is associated with differential engagement of the right supramarginal gyrus as well as hippocampal-cortical reorganization. We also report enhanced hippocampal connectivity to the primary sensory cortex during retrieval of extinguished stimuli following mindfulness training.
conclusionsThese findings suggest hippocampal-dependent changes in contextual retrieval as one plausible neural mechanism through which mindfulness-based interventions enhance fear extinction and foster stress resilience.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.