Evidence map›Paper›PMID 31302897›Full record

ArticleAging clinical and experimental research2020

Arterial stiffness and multiple organ damage: a longitudinal study in population.

Angelo Scuteri, Cristopher H Morrell, Danilo Alunni Fegatelli, Edoardo Fiorillo, Alessandro Delitala, Marco Orru', Michele Marongiu, David Schlessinger, Francesco Cucca

Abstract read
In one paragraph

Article in Aging clinical and experimental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Observational
  5. Usefulness of Arterial Stiffness as an Integrated Marker of Cardiovascular Risk.Journal of clinical hypertension (Greenwich, Conn.) · 2025
    Article
  6. Article
  7. Vascular function: a key player in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Review
  8. Aging of the Arterial System.International journal of molecular sciences · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Angelo ScuteriDepartment of Medical, Surgical, and Experimental Sciences, University of Sassari, Sassari, Italy. ascuteri@uniss.it.ORCID http://orcid.org/0000-0003-4784-5441
Cristopher H MorrellLaboratory of Cardiovascular Sciences, National Institute on Aging Intramural Research Program, NIH, Baltimore, USA.
Danilo Alunni FegatelliDepartment of Public Health and Infectious Disease, University "La Sapienza", Rome, Italy.
Edoardo FiorilloIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Lanusei, NU, Italy.
Alessandro DelitalaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Lanusei, NU, Italy.
Marco Orru'Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Lanusei, NU, Italy.
Michele MarongiuIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Lanusei, NU, Italy.
David SchlessingerLaboratory of Genetics, National Institute on Aging Intramural Research Program, NIH, Baltimore, USA.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.

Funding

Aging-related Traits and Disease Risk Factors in a Sardinian Population CohortZIAAG000675 · NIA · NATIONAL INSTITUTE ON AGING · PI GOROSPE, MYRIAM · 2009 to 2021
$5.7M
Intramural NIH HHS ZIA AG000675NIDA NIH HHS HHSN271201600005CNIDA NIH HHS HHSN271201600005INIH HHS HHSN271201600005C
6 · The paper itself

Abstract

aimsPrevious cross-sectional observation identified arterial aging, indexed as pulse-wave velocity (PWV), as a key determinant of the simultaneous multiple organ damage (heart, carotid artery, and kidney). The aim of the present cohort study is to investigate trajectories of repeated measures of PWV and traditional CV risk factors in subjects who eventually presented clinical evidence of multiple organ damage in the SardiNIA study. METHODS AND

resultsOrgan damage was measured in the heart (left ventricular hypertrophy, LVH), the common carotid artery (intima-media thickness > 0.9 mm and/or plaque), and the kidney (eGFR < 60 ml/min/1.73 m

conclusionsArterial stiffness, a proxy of arterial aging that can be measured clinically as PWV, is an integrated predictive marker of multiple age-associated organ damage recognized as clinical diseases.

Indexed as

Vascular StiffnessAdultCarotid Intima-Media ThicknessCross-Sectional StudiesFemaleGlomerular Filtration RateHumansHypertrophy, Left VentricularKidneyLongitudinal StudiesMaleMiddle AgedPulse Wave AnalysisRetrospective StudiesRisk FactorsArterial stiffnessChronic kidney diseaseLeft ventricular hypertrophyLongitudinal studyMultiple organ damagePulse-wave velocity

Identifiers

PMID31302897
PMCPMC8476312

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.