Evidence map›Paper›PMID 31302830›Full record

ArticleJournal of neuro-oncology2019

A prospective evaluation of whole brain volume loss and neurocognitive decline following hippocampal-sparing prophylactic cranial irradiation for limited-stage small-cell lung cancer.

Chengcheng Gui, Namrata Chintalapati, Russell Kenneth Hales, Khinh Ranh Voong, Haris Iqbal Sair, Jimm Grimm, Mario Duhon, Lawrence Richard Kleinberg, Tracy Dawn Vannorsdall, Kristin Janson Redmond

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Article in Journal of neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chengcheng GuiDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 401 N. Broadway, Baltimore, MD, 21231, USA.
Namrata ChintalapatiDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 401 N. Broadway, Baltimore, MD, 21231, USA.
Russell Kenneth HalesDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 401 N. Broadway, Baltimore, MD, 21231, USA.
Khinh Ranh VoongDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 401 N. Broadway, Baltimore, MD, 21231, USA.
Haris Iqbal SairDepartment of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
Jimm GrimmDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 401 N. Broadway, Baltimore, MD, 21231, USA.
Mario DuhonDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 401 N. Broadway, Baltimore, MD, 21231, USA.
Lawrence Richard KleinbergDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 401 N. Broadway, Baltimore, MD, 21231, USA.
Tracy Dawn VannorsdallDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Kristin Janson RedmondDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 401 N. Broadway, Baltimore, MD, 21231, USA. kjanson3@jhmi.edu.ORCID http://orcid.org/0000-0003-3442-4613

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study evaluated an association between whole brain volume loss and neurocognitive decline following prophylactic cranial irradiation (PCI) for limited-stage small-cell lung cancer (SCLC).

methodsThis was a secondary analysis of a prospective clinical trial that accrued patients at a single institution from 2013 to 2016. Patients with limited-stage SCLC treated with standard chemo-radiation received PCI 25 Gy/10 fractions, with mean hippocampal dose limited to < 8 Gy. Whole brain volumes were measured using MR imaging obtained before and at 6, 12, 18, and 24 months after PCI. Verbal memory was measured by the Hopkins Verbal Learning Test-Revised (HVLT-R) before and at 6 and 12 months after PCI. Univariate and multivariate linear regression evaluated associations between changes in whole brain volume and verbal memory.

resultsTwenty-two patients enrolled. The median whole brain volume before PCI was 1301 mL. Subsequent reduction in whole brain volume was greatest at 18 months after PCI (median change - 23 mL, range - 142 to 20, p = 0.03). At 6 months after PCI, reduction in volume was independently associated with decline in verbal memory, measured by two components of the HVLT-R (Delayed Recall: 0.06/mL volume change, p = 0.046; Percent Retained: 0.66/mL volume change, p = 0.030), when controlling for education and global cognitive function at baseline.

conclusionThis is the first study to correlate reduction in whole brain volume and decline in neurocognitive function following whole brain radiation therapy (WBRT). This suggests that loss of brain volume after WBRT may be clinically significant and subsequently impact cognition and quality of life.

Indexed as

HippocampusAdultAgedBrain NeoplasmsCognition DisordersCranial IrradiationFemaleFollow-Up StudiesHumansLung NeoplasmsMaleMental RecallMiddle AgedNeoplasm StagingOrgan Sparing TreatmentsProspective StudiesCognitive toxicityRadiographic volume lossSmall-cell lung cancerVerbal memoryWhole brain radiation therapy

Identifiers

PMID31302830

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.