Evidence map›Paper›PMID 31302808›Full record

ArticleDigestive diseases and sciences2020

Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study.

Daniel Selvig, Yvette Piceno, Jonathan Terdiman, Martin Zydek, Sarah E Umetsu, Dana Balitzer, Doug Fadrosh, Kole Lynch, Brandon Lamere, Tom Leith and 7 more

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In one paragraph

Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Observational
  7. Approach to Therapy for Chronic Pouchitis.Annual review of medicine · 2025
    Review
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  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Medical management of chronic pouch inflammation.Current research in pharmacology and drug discovery · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Daniel SelvigDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Yvette PicenoDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Jonathan TerdimanDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Martin ZydekDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Sarah E UmetsuDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.
Dana BalitzerDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.
Doug FadroshDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Kole LynchDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Brandon LamereDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Tom LeithOpenBiome, Somerville, MA, USA.
Zain KassamOpenBiome, Somerville, MA, USA.
Kendall BeckDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Sara LewinDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Averil MaDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Ma SomsoukDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Susan V LynchDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Najwa El-NachefDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. najwa.elnachef@ucsf.edu.
University of California, San Francisco · USOpenBiome · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThis pilot study assessed the efficacy, safety, and microbiome dynamics of fecal microbiota transplantation (FMT) for patients with chronic pouchitis.

methodsA prospective open-label pilot study was performed at an academic center among pouchitis patients undergoing FMT. Patients received a minimum of a single FMT by pouchoscopy from healthy, screened donors. The primary outcome was clinical improvement in pouchitis assessed by patient survey at week 4. Secondary outcomes included decrease in total Pouchitis Disease Activity Index (PDAI) Score ≥ 3 at week 4, bowel movement frequency, ESR, CRP, fecal calprotectin, abdominal pain, and PDAI subscores including endoscopic and histologic changes. Stool samples were collected at baseline and 4 weeks post-FMT to assess bacterial microbiota using V4 16S rRNA sequencing.

resultsNineteen patients were enrolled; however, 1 patient was lost to follow-up. No patients had a major adverse event or escalation of therapy related to FMT. Total PDAI scores, endoscopic scores, and histologic scores did not decrease significantly post-FMT. However, there was a statistically significant improvement in bowel movement (BM) frequency (9.25-7.25 BM/day, p = 0.03) and trend for improvement in abdominal pain to improve post-FMT (p = 0.05). Bacterial microbiota profiling revealed no distinct community-level changes post-FMT, though a small number of specific bacterial taxa significantly differed in relative abundance.

conclusionsA single FMT has a tolerable short-term safety profile and may be associated with a decrease in bowel movements in patients with chronic pouchitis; however, no robust endoscopic or histologic changes were observed.

Indexed as

AdolescentAdultAgedEndoscopy, GastrointestinalFecal Microbiota TransplantationFemaleGastrointestinal MicrobiomeHumansMaleMiddle AgedPilot ProjectsPouchitisProspective StudiesYoung AdultDysbiosisFecal microbiota transplantationFMTIBDIPAAMicrobiomePouchitis

Identifiers

PMID31302808
OpenAlexW2958981989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.