ArticleJournal of cancer research and clinical oncology2019
Effects of surgery on survival of elderly patients with stage I small-cell lung cancer: analysis of the SEER database.
Article in Journal of cancer research and clinical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Survival analysis of surgical versus nonsurgical treatment in stage I to III small cell lung cancer in the last 20 years: A systematic review and meta-analysis.Thoracic cancer · 2023Pooled it
- Impact of Surgical Resection on 5-Year Survival in Elderly NSCLC Patients: A SEER Database Analysis With Machine Learning-Based Predictive Modeling in Patients Aged ≥ 60 (2000-2021).Cancer medicine · 2026Article
- Surgical strategy and prognostic factors in very elderly (≥ 75 Years) patients with stage I NSCLC: insights from a propensity score-matched analysis.BMC pulmonary medicine · 2026Article
- Log odds of negative lymph nodes/T stage as a novel predictor of post-resection outcome in non-small cell lung cancer patients.Discover oncology · 2025Article
- PTPMT1 inhibition induces apoptosis and growth arrest of human SCLC cells by disrupting mitochondrial metabolism.Translational cancer research · 2024Article
- The effects of surgical resection in the treatment of limited-stage small cell lung cancer: a multicenter retrospective study.Updates in surgery · 2024Article
- The role of surgery in older patients with T1-2N0M0 small cell lung cancer: A propensity score matching analysis.Frontiers in oncology · 2022Article
- Surgery and Surgery Approach Affect Survival of Patients With Stage I-IIA Small-Cell Lung Cancer: A Study Based SEER Database by Propensity Score Matching Analysis.Frontiers in surgery · 2022Article
- Octogenarians may benefit from stage-specific small cell lung cancer treatment.Translational lung cancer research · 2021Article
- The current role of surgery and SBRT in early stage of small cell lung cancer.Journal of clinical and translational research · 2021Review
- The Role of Tumor Deposits in Predicting the Efficacy of Chemotherapy in Stage III Colon Cancer.Frontiers in oncology · 2020Article
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7 authors.
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Abstract
introductionSurgery improves survival of small-cell lung cancer (SCLC) patients in early stage. However, the role of surgery in the elderly stage I SCLC patients is not well established. We designed this retrospective study to explore the efficacy of surgery on survival of this subset population. PATIENTS AND
methodsElderly patients aged ≥ 75 years with stage I SCLC diagnosed histologically from 1998 to 2013 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Included patients were divided into surgery group (received surgery, accompanied by chemotherapy, radiotherapy, or both or neither), non-surgical group (only received radiotherapy, chemotherapy, or combination), and untreated group. Overall survival (OS) and lung cancer-specific survival (LCSS) were compared among the three groups by the Kaplan-Meier analysis. Cox proportional hazards regression was used to identify factors associated with survival.
resultsA total of 983 patients were included. Among all of the patients, 24.0% patients received surgery, 46.6% patients received non-surgical treatment, and 29.4% patients received no treatment. The 5-year OS rates of surgery, non-surgical and untreated groups were 31%, 12% and 6%, respectively (P < 0.0001). In multivariable analysis, surgery was an important factor that improved OS when compared with non-surgical treatment (HR 0.554; 95% CI 0.458-0.670 [P < 0.0001]). In subgroup analysis, surgery remained an independent factor for OS among patients aged 75-79 years (HR 0.506; 95% CI 0.391-0.655 [P < 0.0001]) and 80-84 years (HR 0.544; 95% CI 0.388-0.763 [P < 0.0001]), while did not reach statistical significance when compared to non-surgical treatment for patients age ≥ 85 years (HR 0.914; 95% CI 0.507-1.650; [P = 0.766]).
conclusionSurgical resection significantly improved OS in stage I SCLC patients aged 75-84 years in our study, but further exploration in larger prospective clinical trials is needed.
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