Evidence map›Paper›PMID 31302753›Full record

ArticleWorld journal of urology2020

Microlocalization and clinical significance of stabilin-1

Bo Wang, Hao Huang, Meihua Yang, Wenjuan Yang, Zhuowei Liu, Weibin Hou, Hong Zeng, Zhihua He, Tianxin Lin, Jian Huang

Open access · hybridAbstract read
In one paragraph

Article in World journal of urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. SubvertingBiology · 2024
    Review
  4. NADJournal for immunotherapy of cancer · 2024
    Article
  5. Article
  6. Review
  7. Clever-1 positive macrophages in breast cancer.Breast cancer research and treatment · 2022
    Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Bo WangDepartment of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.
Hao HuangDepartment of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.
Meihua YangDepartment of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.
Wenjuan YangDepartment of Hematology, Sun Yat-sen Memorial Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China.
Zhuowei LiuDepartment of Urology, Cancer Center, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China.
Weibin HouDepartment of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.
Hong ZengDepartment of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China.
Zhihua HeDepartment of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.
Tianxin LinDepartment of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China. tianxinl@sina.com.
Jian HuangDepartment of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China. urolhj@sina.com.ORCID http://orcid.org/0000-0001-7315-4252
Sun Yat-sen University · CN

Funding

Cultivation of Major Projects and Emerging, Interdisciplinary Fund, Sun Yat-Sen University 16ykjc18Elite Young Scholars Development Program of Sun Yat-Sen Memorial Hospital to Bo Wang; Yat-Sen Scholarship for Young Scientist noneKey Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun-Yat-Sen University KLB09001Key Laboratory of Malignant Tumor Molecular Mechanism and Translational Medicine of Guangzhou Bureau of Science and Information Technology 013-163National Natural Science Foundation of China 81402106National Natural Science Foundation of China 81825016National Natural Science Foundation of Guangdong 2015A030310122Pearl River Nova Program of Guangzhou 201806010024Science and Technology Program of Guangzhou 201604020156Science and Technology Program of Guangzhou 201604020177
6 · The paper itself

Abstract

purposeEmerging evidence has shown that macrophages (Mφs) at different tumor sites have diverse clinical attributes. Stabilin-1 is a multi-functional scavenger marker for specialized tumor-associated Mφs. This study investigates the relationship between the density and microlocalization of stabilin-1

methodsIn this retrospective study, 283 UCB patients who received radical cystectomy or transurethral resection were examined. Immunohistochemistry and immunofluorescence analyses were used to colocalize the expression of stabilin-1 with other markers for Mφs (CD14, CD68, CD163, and CD206). Kaplan-Meier analysis and Cox proportional hazards regression models were applied to estimate overall survival (OS) and recurrence-free survival (RFS).

resultsIn UCB tissues, stabilin-1 was primarily expressed on Mφs, as evident from triple immunofluorescence staining for stabilin-1 and Mφ markers. Stabilin-1

conclusionsOur findings indicate that intratumoral stabilin-1

Indexed as

AgedAntigens, CDAntigens, Differentiation, MyelomonocyticCarcinoma, Transitional CellCD163 AntigenCD68 MoleculeCell Adhesion Molecules, NeuronalDisease-Free SurvivalFemaleHumansLectins, C-TypeLipopolysaccharide ReceptorsMaleMannose-Binding LectinsMannose ReceptorMiddle AgedAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenCD68 antigen, humanCD68 MoleculeCell Adhesion Molecules, NeuronalLectins, C-TypeLipopolysaccharide ReceptorsMannose-Binding LectinsMannose ReceptorReceptors, Cell SurfaceReceptors, Lymphocyte HomingSTAB1 protein, humanMicrolocalizationStabilin-1Tumor-associated macrophagesUrothelial carcinoma of the bladder

Identifiers

PMID31302753
PMCPMC7064462
OpenAlexW2962218100

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.