SynthesisJournal of neurology2019
Deep brain stimulation for Meige syndrome: a meta-analysis with individual patient data.
Synthesis in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- The Efficacy and Predictors of Using GPi-DBS to Treat Early-Onset Dystonia: An Individual Patient Analysis.Neural plasticity · 2021Pooled it
- Predictive factors of outcome in cervical dystonia following deep brain stimulation: an individual patient data meta-analysis.Journal of neurology · 2020Pooled it
- Association of low-frequency oscillations with target selection between the subthalamic nucleus and globus pallidus internus in blepharospasm-oromandibular dystonia.Journal of neurology · 2026Article
- Deep brain stimulation for Meige syndrome.Surgical neurology international · 2025Article
- Putaminal-cortical circuits predict response of bilateral deep brain stimulation of the subthalamic nucleus in the primary Meige syndrome after 5 years.Brain communications · 2025Article
- CT-guided radiofrequency ablation of facial and mandibular nerves in the treatment of compound Meige's syndrome.Neuroradiology · 2024Article
- Pallidal versus subthalamic deep brain stimulation for Meige syndrome: A systematic review and meta-analysis.Heliyon · 2024Article
- Subthalamic nucleus deep brain stimulation in primary Meige syndrome: motor and non-motor outcomes.European journal of neurology · 2024Article
- Progressive thalamic nuclear atrophy in blepharospasm and blepharospasm-oromandibular dystonia.Brain communications · 2024Article
- Review
- Volume of tissue activated within subthalamic nucleus and clinical efficacy of deep brain stimulation in Meige syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Review
- Movement disorders of the mouth: a review of the common phenomenologies.Journal of neurology · 2022Review
- Motor and psychiatric features in idiopathic blepharospasm: A data-driven cluster analysis.Parkinsonism & related disorders · 2022Article
- Clinical Features and Evolution of Blepharospasm: A Multicenter International Cohort and Systematic Literature Review.Dystonia (Lausanne, Switzerland) · 2022Article
- Bilateral pallidal DBS for blepharospasm: A case report and review of the literature.Surgical neurology international · 2022Article
- Patient selection and injection techniques for botulinum neurotoxin in oromandibular dystonia.Clinical parkinsonism & related disorders · 2022Review
- Thalamic Deep Brain Stimulation Is Effective in Alleviating Craniocervical Dystonia.Movement disorders clinical practice · 2021Article
- Arching deep brain stimulation in dystonia types.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Tardive Blepharospasm May Respond to Bilateral Pallidal Deep Brain Stimulation.Tremor and other hyperkinetic movements (New York, N.Y.) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDeep brain stimulation (DBS) is an effective intervention for Meige syndrome, a type of dystonia characterized by blepharospasm, facial, and oromandibular dystonia. This individual patient-level data meta-analysis was to identify the potential outcome predictors, compare the stimulation targets and summarize the efficacy of DBS for Meige syndrome.
methodsThree electronic databases (PubMed, Web of Science and Embase) were searched with no publication data restriction to identify studies regarding DBS for Meige syndrome. The primary outcome was the improvement in BFMDRS-M score. Pearson's correlation coefficients and a stepwise multivariate regression analysis were used to identify the potential prognostic factors.
resultsTwenty-three studies (115 patients, 94 with pallidal stimulation and 21 with subthalamic stimulation) were eligible. Patients showed significant improvement in Burke-Fahn-Marsden Dystonia Rating Scale movement (BFMDRS-M) (21.5 ± 11.0 vs 8.6 ± 6.9, P < 0.001) and disability (BFMDRS-D) (6.4 ± 5.1 vs 2.9 ± 2.4, P < 0.001) scores at the last follow-up visit (31.9 ± 30.7 months), compared with scores at baseline. Preoperative BFMDRS-M and BFMDRS-D scores were positively correlated with the relative changes in BFMDRS-M score at the last follow-up visit. On the stepwise multivariate regression, only the preoperative BFMDRS remained significant in the best predictive model.
conclusionsBased on the existing evidence, pallidal/subthalamic stimulation is an effective therapy for even the refractory Meige syndrome. Higher preoperative scores probably indicate larger improvement. Stimulation targets or other clinical factors do not constitute the outcome predictive factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.