ArticleEuropean heart journal. Cardiovascular Imaging2020
Transient ischaemic dilation and post-stress wall motion abnormality increase risk in patients with less than moderate ischaemia: analysis of the REFINE SPECT registry.
Article in European heart journal. Cardiovascular Imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Subendocardial quantification enhances coronary artery disease detection inEuropean journal of nuclear medicine and molecular imaging · 2025Trial
- Creation of a Standardized Myocardial Perfusion Single-photon Emission Computed Tomography Database to Enhance Coronary Artery Disease Research.Journal of medical signals and sensors · 2026Article
- Multimodality Imaging for Diagnosis of Ischemic Heart Disease in Latin American Women from IAEA (International Atomic Energy Agency) Collaboratory.Current cardiology reports · 2025Review
- Relationship between left ventricular cavity size and transient ischaemic dilation ratio on dipyridamole stress single-photon emission computerized tomography myocardial perfusion imaging in a female Asian population.European heart journal. Imaging methods and practice · 2025Article
- Prognostic value of transient ischemic dilatation byAnnals of nuclear medicine · 2025Article
- The role of deep learning in myocardial perfusion imaging for diagnosis and prognosis: A systematic review.iScience · 2024Review
- The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0).Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- AI-derived epicardial fat measurements improve cardiovascular risk prediction from myocardial perfusion imaging.NPJ digital medicine · 2024Article
- Clinical phenotypes among patients with normal cardiac perfusion using unsupervised learning: a retrospective observational study.EBioMedicine · 2024Observational
- Prognostic value of the left ventricular ejection fraction reserve acquired by gated myocardial perfusion SPECT in patients with CAD and reduced stress LVEF.Frontiers in cardiovascular medicine · 2024Article
- Diagnosis of diffuse ischemia with SPECT relative perfusion imaging: How to eat soup with a fork?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Unsupervised learning to characterize patients with known coronary artery disease undergoing myocardial perfusion imaging.European journal of nuclear medicine and molecular imaging · 2023Article
- Quality metrics for single-photon emission computed tomography myocardial perfusion imaging: an ASNC information statement.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Direct Risk Assessment From Myocardial Perfusion Imaging Using Explainable Deep Learning.JACC. Cardiovascular imaging · 2023Article
- Clinical Application of Myocardial Perfusion SPECT in Patients with Suspected or Known Coronary Artery Disease. What Role in the Multimodality Imaging Era?Reviews in cardiovascular medicine · 2023Review
- Low-dose dobutamine stress gated blood pool SPECT assessment of left ventricular contractile reserve in ischemic cardiomyopathy: a feasibility study.European journal of nuclear medicine and molecular imaging · 2022Article
- Prognostic value of early left ventricular ejection fraction reserve during regadenoson stress solid-state SPECT-MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Is the CZT technology the future of nuclear cardiology?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- CZT camera systems may provide better risk stratification for low-risk patients.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Quantitation of Poststress Change in Ventricular Morphology Improves Risk Stratification.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021Article
Corrections and comments
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Authors and funding
21 authors at 9 institutions in 5 countries.
Funding
Abstract
aimsIschaemia on single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is strongly associated with cardiovascular risk. Transient ischaemic dilation (TID) and post-stress wall motion abnormalities (WMA) are non-perfusion markers of ischaemia with incremental prognostic utility. Using a large, multicentre SPECT MPI registry, we assessed the degree to which these features increased the risk of major adverse cardiovascular events (MACE) in patients with less than moderate ischaemia. METHODS AND
resultsIschaemia was quantified with total perfusion deficit using semiautomated software and classified as: none (<1%), minimal (1 to <5%), mild (5 to <10%), moderate (10 to <15%), and severe (≥15%). Univariable and multivariable Cox proportional hazard analyses were used to assess associations between high-risk imaging features and MACE. We included 16 578 patients, mean age 64.2 and median follow-up 4.7 years. During follow-up, 1842 patients experienced at least one event. Patients with mild ischaemia and TID were more likely to experience MACE compared with patients without TID [adjusted hazard ratio (HR) 1.42, P = 0.023], with outcomes not significantly different from patients with moderate ischaemia without other high-risk features (unadjusted HR 1.15, P = 0.556). There were similar findings in patients with post-stress WMA. However, in multivariable analysis of patients with mild ischaemia, TID (adjusted HR 1.50, P = 0.037), but not WMA, was independently associated with increased MACE.
conclusionIn patients with mild ischaemia, TID or post-stress WMA identify groups of patients with outcomes similar to patients with moderate ischaemia. Whether these combinations identify patients who may derive benefit from revascularization deserves further investigation.
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