ArticleMedical science monitor : international medical journal of experimental and clinical research2019
Low-Frequency Fluctuations Amplitude Signals Exhibit Abnormalities of Intrinsic Brain Activities and Reflect Cognitive Impairment in Leukoaraiosis Patients.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Functional brain changes in vascular cognitive impairment: a whole brain ALE meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- An ALE Meta-Analysis of Specific Functional MRI Studies on Subcortical Vascular Cognitive Impairment.Frontiers in neurology · 2021Pooled it
- Altered Patterns of Amplitude of Low-Frequency Fluctuations and Fractional Amplitude of Low-Frequency Fluctuations Between Amnestic and Vascular Mild Cognitive Impairment: An ALE-Based Comparative Meta-Analysis.Frontiers in aging neuroscience · 2021Pooled it
- Resting-State fMRI Reveals the Neural Correlates of Acupuncture in the Treatment of Vascular Cognitive Impairment.Clinical interventions in aging · 2025Review
- Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia.Frontiers in aging neuroscience · 2025Review
- Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography.Journal of biomedical optics · 2023Article
- Low-frequency oscillations in the brain show differential regional associations with severity of cerebral small vessel disease: a systematic review.Frontiers in neuroscience · 2023Review
- A mini-review on functional magnetic resonance imaging on brain structure of vascular cognitive impairment.Frontiers in neurology · 2023Review
- Dynamic alterations in the amplitude of low-frequency fluctuation in patients with cerebral small vessel disease.Frontiers in molecular neuroscience · 2023Article
- Multimodality neuroimaging in vascular mild cognitive impairment: A narrative review of current evidence.Frontiers in aging neuroscience · 2023Review
- Brain microstructural alterations in the left precuneus mediate the association between KIBRA polymorphism and working memory in healthy adults: a diffusion kurtosis imaging study.Brain imaging and behavior · 2022Article
- Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment.Frontiers in neurology · 2022Review
- Aberrant Amplitude of Low-Frequency Fluctuation and Degree Centrality within the Default Mode Network in Patients with Vascular Mild Cognitive Impairment.Brain sciences · 2021Article
- Brain function state in different phases and its relationship with clinical symptoms of migraine: an fMRI study based on regional homogeneity (ReHo).Annals of translational medicine · 2021Article
- Neuroimaging Anomalies in Community-Dwelling Asymptomatic Adults With Very Early-Stage White Matter Hyperintensity.Frontiers in aging neuroscience · 2021Article
- Brain Functional Changes in Stroke Following Rehabilitation Using Brain-Computer Interface-Assisted Motor Imagery With and Without tDCS: A Pilot Study.Frontiers in human neuroscience · 2021Article
- Altered amplitude of low-frequency fluctuations and default mode network connectivity in high myopia: a resting-state fMRI study.International journal of ophthalmology · 2020Article
- Cerebrovascular Reactivity Mapping Without Gas Challenges: A Methodological Guide.Frontiers in physiology · 2020Review
- Abnormal Interactions of the Salience Network, Central Executive Network, and Default-Mode Network in Patients With Different Cognitive Impairment Loads Caused by Leukoaraiosis.Frontiers in neural circuits · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND This study aimed to explore the amplitude of low-frequency fluctuations (ALFF) for whole-brain in leukoaraiosis (LA) patients suffering from cognitive decline or impairment. MATERIAL AND METHODS Patients were selected by employing magnetic resonance imaging (MRI) technique. According to results of the clinical dementia rating and Montreal cognitive assessment (MoCA), patients were divided into 3 groups: LA patients diagnosed as vascular mild-cognitive impairment (LA-VaMCI, n=28), LA patients diagnosed as vascular-dementia (LA-VaD, n=18), and normal individuals (NC, n=28). Executive functions were evaluated by using the Stroop test and Trail Making Test (TMT). The higher scores in TMT test mean greater impairments. Changes for the ALFF were measured by using resting-state functional MRI (rs-fMRI) technique. Correlations between ALFF and cognition scores were analyzed. RESULTS It was found that widespread differences in ALFF were present predominantly in the posterior cingulate cortex/precuneus (PCC/PCu) and in the right inferior temporal gyrus (ITG). Compared with the NC group, ALFF values in PCC/PCu were significantly decreased (F=3.273, P=0.022) and ALFF values were significantly increased (F=2.864, P=0.033) in temporal regions of the LA-VaD patients. ALFF values in LA-VaMCI patients were significantly increased in ITG compared to that in the NC group (F=1.064, P=0.042) and the LA-VaD group (F=2.725, P=0.037). Impairment in executive functions were positively correlated with average ALFF of the left PCu. CONCLUSIONS This research showed that LA patients exhibited abnormal intrinsic-brain activities. Furthermore, altered ALFF was positively correlated with executive function scores.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.