Evidence map›Paper›PMID 31302525›Full record

Trial reportJournal of affective disorders2019

The MARIGOLD study: Feasibility and enhancement of an online intervention to improve emotion regulation in people with elevated depressive symptoms.

Elizabeth L Addington, Elaine O Cheung, Sarah M Bassett, Ian Kwok, Stephanie A Schuette, Eva Shiu, Dershung Yang, Michael A Cohn, Yan Leykin, Laura R Saslow and 1 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of affective disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04367922 (A Positive Affect Regulation sKills Intervention to Decrease Stress During a Pandemic), which is not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04367922 nacompletednot on this mapstarted 2020, after this paper: background citation

A Positive Affect Regulation sKills Intervention to Decrease Stress During a Pandemic: A Single Arm, Non-Randomized Trial of a Public Platform

TypeinterventionalSponsorNorthwestern UniversityRan2020 to 2023Enrolled1,000ConditionsAnxiety, Depression, Social IsolationArmsPositive Emotion Skills Course
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Elizabeth L AddingtonDepartment of Medical Social Sciences, Osher Center for Integrative Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: elizabeth.addington@northwestern.edu.
Elaine O CheungDepartment of Medical Social Sciences, Osher Center for Integrative Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Sarah M BassettDepartment of Medical Social Sciences, Osher Center for Integrative Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Ian KwokDepartment of Medical Social Sciences, Osher Center for Integrative Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Stephanie A SchuetteDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Eva ShiuDepartment of Medical Social Sciences, Osher Center for Integrative Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Dershung YangBrightOutcome, Inc, USA.
Michael A CohnOsher Center for Integrative Medicine, University of California, San Francisco, San Francisco, CA, USA.
Yan LeykinPalo Alto University, Palo Alto, CA, USA.
Laura R SaslowDepartment of Health Behavior and Biological Sciences, School of Nursing, University of Michigan, Ann Arbor, MI, USA.
Judith T MoskowitzDepartment of Medical Social Sciences, Osher Center for Integrative Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Northwestern University · USBrightOutcome (United States) · USDuke University · USPalo Alto University · USUniversity of California, San Francisco · USUniversity of Michigan · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3M
The University of Chicago and Northwestern University Predoctoral Health Services Research Program-RenewalT32HS000084 · AHRQ · UNIVERSITY OF CHICAGO · PI KONETZKA, RITA TAMARA, MELTZER, DAVID O · 1998 to 2024
$7.6M
Cancer Prevention, Control, and Survivorship Research Training ProgramT32CA193193 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Brian L Hitsman, BETINA YANEZ · 2015 to 2026
$3.8M
Optimization of a Multicomponent Diet Intervention in Type 2 DiabetesK01DK107456 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SASLOW, LAURA · 2016 to 2020
$777k
Positive affect skills for depression: Optimizing internet and mobile deliveryR34MH101265 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MOSKOWITZ, JUDITH T. · 2014 to 2016
$672k
AHRQ HHS T32 HS000084NCATS NIH HHS UL1 TR001422NCI NIH HHS T32 CA193193NIDDK NIH HHS K01 DK107456NIDDK NIH HHS P30 DK020572NIMH NIH HHS R34 MH101265
6 · The paper itself

Abstract

backgroundThis manuscript describes the first two phases of pilot testing MARIGOLD, an online self-guided positive emotion skills intervention for adults with elevated depressive symptoms, along with enhancements to overcome retention and adherence problems reported in previous research.

methodsAdults with elevated depressive symptoms were recruited online and assessed at baseline, post-intervention, 1- and 3-month follow-up. Phase 1 participants (n = 58) were randomized to MARIGOLD, daily emotion reporting, or waitlist. Phase 2 participants (n = 79) were randomized to MARIGOLD plus one enhancement: online discussion board (ODB), virtual badges (VB), or facilitator contact (FC). Post-intervention interviews assessed acceptability. Intention-to-treat analyses examined retention, adherence, and preliminary efficacy.

resultsIn both phases, retention and adherence did not differ between groups. MARIGOLD skills were highly acceptable, but qualitative results indicate web-based features (e.g., log-in, ODB, VB) require refinement prior to larger testing. Neither phase demonstrated between-group differences in preliminary efficacy. In Phase 1 within-group analyses, MARIGOLD and emotion reporting control demonstrated a similar pattern of findings (stable depressive symptoms, increased positive emotion, decreased negative emotion and stress), whereas the waitlist group significantly increased in depressive mood. Most Phase 2 within-group analyses demonstrated the expected pattern of results (i.e., decreases in PHQ-8 and negative emotion, increases in positive emotion). However, CES-D scores were stable in FC; perceived stress was stable in FC and ODB. LIMITATIONS: This pilot study is not powered to evaluate efficacy.

conclusionPositive emotion skills, plus enhancements for web-based, self-guided delivery, warrant additional study in people with elevated depressive symptoms.

Indexed as

AffectAdultCognitive Behavioral TherapyDepressionEmotional RegulationFeasibility StudiesFemaleHealth BehaviorHumansInternetInternet-Based InterventionMaleMiddle AgedPatient Education as TopicPilot ProjectsTreatment OutcomeDepressionEmotionsHappinessInternetTelemedicine

Identifiers

PMID31302525
PMCPMC6711819
OpenAlexW2955701562

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.