Evidence map›Paper›PMID 31302432›Full record

ArticleEnvironmental toxicology and pharmacology2019

Comparison of the reactivation rates of acetylcholinesterase modified by structurally different organophosphates using novel pyridinium oximes.

Sandip B Bharate, Chih-Kai Chao, Charles M Thompson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental toxicology and pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Sandip B BharateThe Center for Structural and Functional Neuroscience, Department of Biomedical and Pharmaceutical Sciences, The University of Montana, Missoula, MT, 59812, USA; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India. Electronic address: sbharate@iiim.ac.in.
Chih-Kai ChaoThe Center for Structural and Functional Neuroscience, Department of Biomedical and Pharmaceutical Sciences, The University of Montana, Missoula, MT, 59812, USA.
Charles M ThompsonThe Center for Structural and Functional Neuroscience, Department of Biomedical and Pharmaceutical Sciences, The University of Montana, Missoula, MT, 59812, USA. Electronic address: chuck.thompson@mso.umt.edu.
University of Montana · USIndian Institute of Integrative Medicine · IN

Funding

Understanding the molecular mechanism of pathogenesis of prion diseasesP20RR015583 · NCRR · UNIVERSITY OF MONTANA · PI KAVANAUGH, MICHAEL PATRICK · 2000 to 2009
$17.6M
Core Laboratory for Neuromolecular ProductionP30NS055022 · NINDS · UNIVERSITY OF MONTANA · PI THOMPSON, CHARLES MARK · 2008 to 2013
$4.2M
Molecular Imaging of Chemical Threats and CountermeasuresU01NS092495 · NINDS · UNIVERSITY OF MONTANA · PI GERDES, JOHN M, THOMPSON, CHARLES MARK · 2015 to 2019
$3.9M
NCRR NIH HHS P20 RR015583NINDS NIH HHS P30 NS055022NINDS NIH HHS U01 NS092495
6 · The paper itself

Abstract

A novel panel of oximes were synthesized, which have displayed varying degree of reactivation ability towards different organophosphorus (OP) modified cholinesterases. In the present article, we report a comparative reactivation profile of a series of quaternary pyridinium-oximes for electric eel acetylcholinesterase (EEAChE) inhibited by the organophosphorus (OP) inhibitors methyl paraoxon (MePOX), ethyl paraoxon (POX; paraoxon) and diisopropyl fluorophosphate (DFP) that are distinguishable as dimethoxyphosphoryl, diethoxyphosphoryl and diisopropoxyphosphoryl AChE-OP-adducts. Most of the 59-oximes tested led to faster and more extensive reactivation of MePOX- and POX-inhibited EEAChE as compared to DFP-modified EEAChE. All were effective reactivators of three OP-modified EEAChE conjugates showing 18-21% reactivation for DFP-inhibited AChE and ≥45% reactivation for MePOX- and POX-inhibited EEAChE. Oximes 7 and 8 showed k

Indexed as

AcetylcholinesteraseAnimalsCholinesterase InhibitorsCholinesterase ReactivatorsDrug DesignElectrophorusMolecular Docking SimulationMolecular StructureNerve AgentsOrganophosphate PoisoningOrganophosphorus CompoundsOximesPyridinium CompoundsAcetylcholinesteraseCholinesterase InhibitorsCholinesterase ReactivatorsNerve AgentsOrganophosphorus CompoundsOximesPyridinium CompoundsAgingDiisopropyl fluorophosphateElectric eel AChEEthyl paraoxonMethyl paraoxonPyridinium oximesReactivation

Identifiers

PMID31302432
PMCPMC6736693
OpenAlexW2953780995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.