Evidence map›Paper›PMID 31302218›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2020

Attention-Deficit/Hyperactivity Disorder Medication and Unintentional Injuries in Children and Adolescents.

Laura Ghirardi, Henrik Larsson, Zheng Chang, Qi Chen, Patrick D Quinn, Kwan Hur, Robert D Gibbons, Brian M D'Onofrio

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Article
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  11. Observational
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  14. Trends in Parent-Reported ADHD Diagnosis and Treatment Among U.S. Children, 2016-2023.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Article
  15. ADHD Prevalence Among U.S. Children and Adolescents in 2022: Diagnosis, Severity, Co-Occurring Disorders, and Treatment.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Laura GhirardiKarolinska Institutet, Stockholm, Sweden. Electronic address: laura.ghirardi@ki.se.
Henrik LarssonKarolinska Institutet, Stockholm, Sweden; School of Medical Sciences, Örebro University, Örebro, Sweden.
Zheng ChangKarolinska Institutet, Stockholm, Sweden.
Qi ChenKarolinska Institutet, Stockholm, Sweden.
Patrick D QuinnSchool of Public Health, Indiana University, Bloomington.
Kwan HurCenter for Health Statistics, University of Chicago, Illinois.
Robert D GibbonsCenter for Health Statistics, University of Chicago, Illinois.
Brian M D'OnofrioKarolinska Institutet, Stockholm, Sweden; Indiana University, Bloomington.
Karolinska Institutet · SEUniversity of Chicago · USIndiana University Bloomington · US

Funding

Risks and Benefits of ADHD Medication for Psychiatric and Neurologic ProblemsR01MH102221 · NIMH · TRUSTEES OF INDIANA UNIVERSITY · PI D'ONOFRIO, BRIAN M, LARSSON, HENRIK · 2014 to 2017
$1.7M
Pharmacoepidemiologic Studies of Prescription Opioid Analgesic RisksR00DA040727 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI QUINN, PATRICK DONOVAN · 2018 to 2020
$744k
Pharmacoepidemiologic Studies of Prescription Opioid Analgesic RisksK99DA040727 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI QUINN, PATRICK DONOVAN · 2016 to 2017
$275k
NIDA NIH HHS K99 DA040727NIDA NIH HHS R00 DA040727NIMH NIH HHS R01 MH102221
6 · The paper itself

Abstract

objectiveOur objective was to determine whether attention-deficit/hyperactivity disorder (ADHD) medication is associated with a decreased risk of unintentional injuries in children and adolescents in the United States across sexes, age groups and injury types.

methodWe used de-identified inpatient, outpatient, and filled prescription claims data from the Truven Health MarketScan Research Databases. Individuals were followed from January 1, 2005, date of first ADHD diagnosis, or medication prescription, or age 6 years, whichever occurred last, until December 31, 2014, first healthcare insurance disenrollment, or the first year at which their age was recorded as 19 years, whichever occurred first. A person was considered on ADHD medication during a given month if a prescription was filled in that month. The outcome was defined as emergency department visits for injuries, including traumatic brain injuries, with unintentional causes. Odds of having the outcome were compared between medicated and unmedicated months at the population-level and in within-individual analyses using logistic regression.

resultsAmong 1,968,146 individuals diagnosed with ADHD or receiving ADHD medication, 87,154 had at least one event. At the population level, medication use was associated with a lower risk of injuries, both in boys (odds ratio [OR] = 0.85; 95% CI = 0.84-0.86) and girls (OR = 0.87; 95% CI = 0.85-0.89). Similar results were obtained from within-individual analysis among male (OR = 0.72; 95% CI = 0.70-0.74) and female (OR = 0.72; 95% CI = 0.69-0.75) children, and among male (OR = 0.64; 95% CI = 0.60-0.67) and female (OR = 0.65; 95% CI = 0.60-0.71) adolescents. Similar results were found for traumatic brain injuries.

conclusionADHD medication use was associated with a reduction of different types of unintentional injuries in children and adolescents of both sexes.

Indexed as

Attention Deficit Disorder with HyperactivityCentral Nervous System StimulantsAdolescentAdultChildDatabases, FactualDrug PrescriptionsEmergency Service, HospitalFemaleHumansMaleRiskUnited StatesYoung AdultCentral Nervous System Stimulantsattention-deficit disorder with hyperactivity/drug therapy

Identifiers

PMID31302218
PMCPMC6954332
OpenAlexW2959936147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.