ArticleMolecular metabolism2019
Evaporative cooling provides a major metabolic energy sink.
Article in Molecular metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gut Microbial Community and Host Thermoregulation in Small Mammals.Frontiers in physiology · 2022Pooled it
- DGAT1 regulates keratinocyte proliferation through the modulation of retinoid homeostasis.Journal of physiology and biochemistry · 2026Article
- Humidity impacts volatile anesthetic and heat responses of malignant hyperthermia susceptible mice.Skeletal muscle · 2026Article
- Dietary lipids are largely deposited in skin and rapidly affect insulating properties.Nature communications · 2025Article
- Hydration Considerations to Improve the Physical Performance and Health of Firefighters.Journal of functional morphology and kinesiology · 2024Review
- Lazy neutrophils - a lack of DGAT1 reduces the chemotactic activity of mouse neutrophils.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease.Cell metabolism · 2024Article
- Regulation of metabolic health by dietary histidine in mice.The Journal of physiology · 2023Article
- Contrasting recruitment of skin-associated adipose depots during cold challenge of mouse and human.The Journal of physiology · 2022Article
- PGC-1β-expressing POMC neurons mediate the effect of leptin on thermoregulation in the mouse.Scientific reports · 2020Article
- Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects.Cell metabolism · 2020Article
- Adipogenesis in Different Body Depots and Tumor Development.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectiveElimination of food calories as heat could help redress the excess accumulation of metabolic energy exhibited as obesity. Prior studies have focused on the induction of thermogenesis in beige and brown adipose tissues as the application of this principle, particularly because the β-adrenergic environment associated with thermogenic activation has been shown to have positive health implications. The counterpoint to this strategy is the regulation of heat loss; we propose that mammals with inefficient heat conservation will require more thermogenesis to maintain body temperature.
methodsSurface temperature thermography and rates of trans-epidermal water loss were integrated to profile the total heat transfer of genetically-engineered and genetically variable mice.
resultsThese data were incorporated with energy expenditure data to generate a biophysical profile to test the significance of increased rates of evaporative cooling.
conclusionsWe show that mouse skins vary considerably in their heat retention properties, whether because of naturally occurring variation (SKH-1 mice), or genetic modification of the heat-retaining lipid lamellae (SCD1, DGAT1 or Agouti A
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.