Evidence map›Paper›PMID 31301335›Full record

ArticleNeuropharmacology2019

AMP-activated protein kinase slows D2 dopamine autoreceptor desensitization in substantia nigra neurons.

Wei Yang, Adam C Munhall, Steven W Johnson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Wei YangDepartment of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA.
Adam C MunhallVeterans Affairs Portland Health Care System, Portland, OR, 97239, USA.
Steven W JohnsonDepartment of Neurology, Oregon Health & Science University, Portland, OR, 97239, USA; Veterans Affairs Portland Health Care System, Portland, OR, 97239, USA. Electronic address: johnsost@ohsu.edu.
VA Portland Health Care System · USOregon Health & Science University · US

Funding

Regulation of VTA dopamine neurons by AMP kinaseR01DA038208 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI JOHNSON, STEVEN WILLIAM · 2014 to 2017
$1.3M
Regulation of VTA dopamine neurons by AMP kinaseI01BX002525 · VA · PORTLAND VA MEDICAL CENTER · PI JOHNSON, STEVEN WILLIAM · 2015 to 2018
–
BLRD VA I01 BX002525NIDA NIH HHS R01 DA038208
6 · The paper itself

Abstract

Dopamine neurons in the substantia nigra zona compacta (SNC) are well known to express D2 receptors. When dopamine is released from somatodendritic sites, activation of D2 autoreceptors suppresses dopamine neuronal activity through activation of G protein-coupled K

Indexed as

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAMP-Activated Protein KinasesAnimalsAutoreceptorsBiphenyl CompoundsCyclic AMP-Dependent Protein KinasesDopamineDopamine AgonistsEnzyme ActivatorsGuanine Nucleotide Exchange FactorsNeuronsPars CompactaPatch-Clamp TechniquesPyrimidinesPyronesQuinpirole2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrileAMP-Activated Protein KinasesAutoreceptorsBiphenyl CompoundsCyclic AMP-Dependent Protein KinasesDopamineDopamine AgonistsEnzyme ActivatorsGuanine Nucleotide Exchange FactorsPyrimidinesPyronesQuinpiroleRapgef4 protein, ratReceptors, Dopamine D2ThiophenesZLN024AMP kinaseD1 receptorD2 autoreceptorDesensitizationDopamineSubstantia nigra

Identifiers

PMID31301335
PMCPMC6745265
OpenAlexW2961897343

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.