ArticleThe American journal of clinical nutrition2019
Improving fruit and vegetable intake attenuates the genetic association with long-term weight gain.
Article in The American journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Interactions between Polygenic Risk of Obesity and Dietary Factors on Anthropometric Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.The Journal of nutrition · 2024Pooled it
- Local Food System Approaches to Address Food and Nutrition Security among Low-Income Populations: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2024Pooled it
- Associations and interaction effects of socioeconomic, lifestyle, and genetic factors on intrinsic capacity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Interaction between a refined carbohydrate dietary pattern and genetic risk score for obesity in the Korean population.Public health nutrition · 2026Article
- Interaction between polygenic scores and dietary intake in relation to BMI in Canadian children.Journal of nutritional science · 2026Article
- Impact of dietary transitions on overweight and obesity burden and future trends among Chinese adults.NPJ science of food · 2025Article
- Association of Veggie Meter-Assessed Skin Carotenoids and Dietary Intake Among Indigenous Families: The Indigenous Supported Agriculture "Go Healthy" Study.Current developments in nutrition · 2025Article
- Mediterranean diet and obesity polygenic risk interaction on adiposity in European children: The IDEFICS/I.Family Study.Pediatric obesity · 2025Article
- Impact of the Dinner Tonight Healthy Cooking School on Participants' Nutrition Knowledge and Cooking Confidence.Nutrients · 2025Article
- The Interaction Between Body Mass Index Genetic Risk Score and Dietary Intake on Weight Status: A Systematic Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Risk Factors for Diabetes and Cardiovascular Complications in the Chinese Population.China CDC weekly · 2023Article
- Interaction between genetic susceptibility to obesity and food intake on BMI in Finnish school-aged children.Scientific reports · 2023Article
- Integration of methylation quantitative trait loci (mQTL) on dietary intake on DNA methylation levels: an example of n-3 PUFA and ABCA1 gene.European journal of clinical nutrition · 2023Article
- Toward Precision Weight-Loss Dietary Interventions: Findings from the POUNDS Lost Trial.Nutrients · 2023Review
- Does colour variety accurately quantify nutritional value in children's lunchboxes? A pilot study.Public health in practice (Oxford, England) · 2023Article
- Association between Diet and Adiposity in Adults: Influence of Sedentary Behavior Patterns.Healthcare (Basel, Switzerland) · 2023Article
- Article
- Meeting report: plant-rich dietary patterns and health.The Proceedings of the Nutrition Society · 2022Review
- Genetic Predisposition, Fruit Intake and Incident Stroke: A Prospective Chinese Cohort Study.Nutrients · 2022Article
- The energy balance model of obesity: beyond calories in, calories out.The American journal of clinical nutrition · 2022Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundWhether changes in fruit and vegetable intake can modify the effect of genetic susceptibility to obesity on long-term changes in BMI and body weight are uncertain.
objectiveWe analyzed the interactions of changes in total and specific fruit and vegetable intake with genetic susceptibility to obesity in relation to changes in BMI and body weight.
methodsWe calculated a genetic risk score on the basis of 77 BMI-associated loci to determine the genetic susceptibility to obesity, and examined the interactions of changes in total and specific fruit and vegetable intake with the genetic risk score on changes in BMI and body weight within five 4-y intervals over 20 y of follow-up in 8943 women from the Nurses' Health Study (NHS) and 5308 men from the Health Professionals Follow-Up Study (HPFS).
resultsIn the combined cohorts, repeated 4-y BMI change per 10-risk allele increment was 0.09 kg/m2 among participants with the greatest decrease in total fruit and vegetable intake and -0.02 among those with the greatest increase in intake (P-interaction <0.001; corresponding weight change: 0.20 kg compared with -0.06 kg). The magnitude of decrease in BMI associated with increasing fruit and vegetable intake was more prominent among participants with high genetic risk than those with low risk. Reproducible interactions were observed for fruits and vegetables separately (both P-interaction <0.001). Based on similar nutritional content, the interaction effect was greatest for berries, citrus fruits, and green leafy vegetables, and the interaction pattern persisted regardless of the different fiber content or glycemic load of fruits and vegetables.
conclusionsGenetically associated increased BMI and body weight could be mitigated by increasing fruit and vegetable intake, and the beneficial effect of improving fruit and vegetable intake on weight management was more pronounced in individuals with greater genetic susceptibility to obesity.
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