Evidence map›Paper›PMID 31301099›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2019

Survival outcomes of allogeneic hematopoietic cell transplants with EBV-positive or EBV-negative post-transplant lymphoproliferative disorder, A CIBMTR study.

Seema Naik, Marcie Riches, Parameswaran Hari, Soyoung Kim, Min Chen, Carlos Bachier, Paul Shaughnessy, Joshua Hill, Per Ljungman, Minoo Battiwalla and 23 more

Abstract read
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 20 institutions in 5 countries.

Seema NaikPenn State Cancer Institute, Hershey, Pennsylvania.ORCID https://orcid.org/0000-0002-9859-151X
Marcie RichesDivision of Hematology/Oncology, The University of North Carolina, Chapel Hill, North California.
Parameswaran HariDepartment of Medicine, Medical College of Wisconsin, Center for International Blood and Marrow Transplant Research (CIBMTR), Milwaukee, Wisconsin.
Soyoung KimDepartment of Medicine, Medical College of Wisconsin, Center for International Blood and Marrow Transplant Research (CIBMTR), Milwaukee, Wisconsin.
Min ChenDepartment of Medicine, Medical College of Wisconsin, Center for International Blood and Marrow Transplant Research (CIBMTR), Milwaukee, Wisconsin.
Carlos BachierSarah Cannon Center for Blood Cancer, Nashville, Tennessee.
Paul ShaughnessyTexas Transplant Institute, Sarah Cannon Blood Cancer Network, San Antonio, Texas.
Joshua HillFred Hutchinson Cancer Research Center, Seattle, Washington.
Per LjungmanDepartment of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden.
Minoo BattiwallaSarah Cannon Center for Blood Cancer, Nashville, Tennessee.
Saurabh ChhabraDepartment of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin.
Andrew DalyTom Baker Cancer Centre, Calgary, AB, Canada.
Jan StorekDepartment of Medicine, University of Calgary, Calgary, AB, Canada.
Celalettin UstunDivision of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, Minnesota.
Miguel Angel DiazDepartment of Hematology/Oncology, Hospital Infantil Universitario Nino Jesus, Madrid, Spain.
Jan CernyUMass Memorial Medical Center, Worcester, Massachusetts.
Amer BeitinjanehUniversity of Miami, Miami, Florida.
Jean YaredBlood & Marrow Transplantation Program, Division of Hematology/Oncology, Department of Medicine, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland.
Valerie BrownDivision of Pediatric Oncology/Hematology, Department of Pediatrics, Penn State Hershey Children's Hospital and College of Medicine, Hershey, Pennsylvania.
Kristin PageDivision of Pediatric Blood and Marrow Transplantation, Duke University Medical Center, Durham, North Carolina.
Parastoo B DahiDepartment of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Siddhartha GangulyDivision of Hematological Malignancy and Cellular Therapeutics, University of Kansas Health System, Kansas City, Kansas.
Sachiko SeoDepartment of Hematology, Oncology, Dokkyo Medical University, Tochigi, Japan.
Nelson ChaoDivision of Cell Therapy and Hematologica, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Cesar O FreytesTexas Transplant Institute, Sarah Cannon Blood Cancer Network, San Antonio, Texas.
Ayman SaadDivision of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Bipin N SavaniDivision of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Kwang Woo AhnDepartment of Medicine, Medical College of Wisconsin, Center for International Blood and Marrow Transplant Research (CIBMTR), Milwaukee, Wisconsin.
Michael BoeckhVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Helen E HeslopDivision of Hematology and Oncology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas.
Hillard M LazarusSeidman Cancer Center, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio.
Jeffery J AulettaBlood and Marrow Transplant Program and Host Defense Program, Divisions of Hematology/Oncology/Bone Marrow Transplant and Infectious Diseases, Nationwide Children's Hospital, Columbus, Ohio.
Rammurti T KambleDivision of Hematology and Oncology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas.
Medical College of Wisconsin · USSarah Cannon · USBaylor College of Medicine · USFred Hutch Cancer Center · USPenn State Milton S. Hershey Medical Center · USDokkyo Medical University · JPDuke Medical Center · USDuke University · USHospital Infantil Universitario Niño Jesús · ESKarolinska University Hospital · SEMemorial Sloan Kettering Cancer Center · USNationwide Children's Hospital · USUMass Memorial Health Care · USUniversity Hospitals Seidman Cancer Center · USUniversity of Alabama at Birmingham · USUniversity of Calgary · CAUniversity of Kansas · USUniversity of Maryland, Baltimore · USUniversity of Miami · USUniversity of Minnesota Medical Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Data commons for 'omic, microscopy and analysis core facilitiesS10OD018164 · OD · DUKE UNIVERSITY · PI WRAY, GREGORY A. · 2014 to 2014
$598k
NCI NIH HHS P30 CA008748NCI NIH HHS U24 CA076518NIH HHS S10 OD018164
6 · The paper itself

Abstract

backgroundPost-transplant lymphoproliferative disorders (PTLD) are associated with significant morbidity and mortality following allogeneic hematopoietic cell transplant (alloHCT). Although most PTLD is EBV-positive (EBV

methodsBetween 2002 and 2014, 432 cases of PTLD following alloHCT were reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). After exclusions, 267 cases (EBV

resultsTwo hundred and eight patients (78%) received in vivo T-cell depletion (TCD) with either anti-thymocyte globulin (ATG) or alemtuzumab. Incidence of PTLD was highest using umbilical cord donors (UCB, 1.60%) and lowest using matched related donors (MRD, 0.40%). Clinical features and histology did not significantly differ among EBV

conclusionsThere is no difference in survival outcomes for patients with EBV

Indexed as

Transplantation ConditioningAdolescentAdultAgedChildChild, PreschoolEpstein-Barr Virus InfectionsFemaleHematopoietic Stem Cell TransplantationHerpesvirus 4, HumanHumansIncidenceInfantLymphoproliferative DisordersMaleMiddle Agedallogeneic hematopoietic cell transplantEpstein-Barr viruspost-transplant lymphoproliferative disorder

Identifiers

PMID31301099
PMCPMC7239317
OpenAlexW2961765674

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.