ArticleThe journal of physiological sciences : JPS2019
Effects of testosterone on circadian rhythmicity in old mice.
Article in The journal of physiological sciences : JPS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Application of Machine Learning Models to Identify Differences in Neural Electrophysiological Properties Across Estrous Cycle Phases.Neuroinformatics · 2026Article
- Sleep disruption from inhalation of biomass smoke: a basis for coincident hypertension?Particle and fibre toxicology · 2025Article
- Sustained Accumulation of Molecular Clock Suppressors Period 1 and Period 2 Promotes C2C12 Myotube Atrophy Through an Autocrine-Mediated Mechanism With Relevance to Androgen Deprivation-Induced Limb Muscle Mass Loss.Function (Oxford, England) · 2025Article
- Guidelines for sex-specific considerations to improve rigor in renal research and how we got there.American journal of physiology. Renal physiology · 2025Review
- Inputs and Outputs of the Mammalian Circadian Clock.Biology · 2023Review
- Reshaping the Gut Microbiota Through Lifestyle Interventions in Women with PCOS: A Review.Indian journal of microbiology · 2022Review
- Oak extracts modulate circadian rhythms of clock gene expression in vitro and wheel-running activity in mice.Sleep and biological rhythms · 2022Article
- Sex Hormone Suppression and Physical Activity: Possible Implications for Transgender Individuals.Transgender health · 2022Article
- A high-salt/high fat diet alters circadian locomotor activity and glucocorticoid synthesis in mice.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Serum testosterone concentration decreases with age in humans and rodents. Accordingly, old male mice show changes in locomotor activity rhythms: a lengthened free-running period and decreased activity levels among others. To investigate whether testosterone replacement improves the age-related decline in circadian rhythmicity, we examined the effects of testosterone on the circadian rhythms of wheel running activity in old male mice. Intact male C57BL/6J mice (18-22 months old) were subcutaneously implanted with silicone tubes packed with testosterone propionate (TP) or cholesterol. TP treatment significantly decreased the daily wheel running revolutions in a normal light/dark (LD) cycle and in constant darkness (DD), but did not affect the free-running period. The same experiment performed on young male gonadectomized mice (3-5 months old) demonstrated that TP treatment significantly increased activity levels in both LD and DD. These results suggest that testosterone replacement exacerbates the age-related decline in circadian rhythmicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.